Results 141 to 150 of about 4,341,666 (299)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A novel eco-friendly HPTLC approach for the simultaneous determination of erdosteine, ibuprofen and pseudoephedrine pharmaceutical combination

Scientific Reports
This paper introduces the first validated and ecofriendly high-performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of erdosteine (ERD), ibuprofen (IBU), and pseudoephedrine (PSE) pharmaceutical combination.
Feda A. H. Elgammal, Maram G. Hafez, Hadeel A. Khalil, Dina A. Gawad, Tarek S. Belal   +4 more
doaj   +1 more source

Greenness metrics for analytical methodologies linked to mass spectrometry

Green Analytical Chemistry
With a global focus on sustainability and environmental impact, scientists have been prompted to adopt eco-friendly practices. Green analytical chemistry (GAC) promotes energy-efficient equipment, reduction of toxic chemicals, and sustainable waste ...
Marina Jurisch, Júlia Célia Lima Gomes, Brícia Marques Parreiras, João Victor Coelho Pimenta, Túlio Miranda Sepulveda, Adriana Nori de Macedo, Brenda Lee Simas Porto, Rodinei Augusti   +7 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

What can e-assessment do for learning and teaching? Part 1 of a draft of current and emerging practice review by the e-Assessment Association expert panel

, 2012
This paper serves as part of a review by the e-Assessment Association (eAA) in its desire to make a positive contribution to the assessment arena.
Beevers, Cliff, al., et
core  

The Earth's Terrestrial Biodiversity Hotspots in Land Use Debt

Earth's Future
Land‐use change is a primary driver of ecosystem degradation in terrestrial biodiversity hotspots, undermining global sustainability commitments. However, tracking progress under the Land Degradation Neutrality (LDN) policy, which aims to balance ...
Patient Mindje Kayumba, Yaning Chen, Li Zhi, Richard Mind'je, Sikandar Ali   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Peer assessment assisted by technology

, 2012
A common theme from the National Student Survey is that students want more feedback, but increasing the amount of teacher-student feedback is not practicable. Peer assessment, if carefully supported, can be a cost-effective solution.
Barr, Niall, Hamer, John, Brown, C., Hamer, J., Honeychurch, Sarah, Brown, Craig, Honeychurch, S., Barr, N.   +7 more
core  

Greenness assessment of microextractiontechniques in therapeutic drug monitoring: supplementary materials

Aim: In this study, we evaluated the greenness and whiteness scores for microextraction techniques usedin therapeutic drug monitoring. Additionally, the cons and pros of each evaluated method and theirimpacts on the provided scores are also discussed ...
Seyed Mosayeb Daryanavard (18176156), Parastoo Hosseini Pour (18176152), Foad Mashayekhi Suzaei (18176154)   +2 more
core   +1 more source