Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The investigation of learner-assessment interaction in learning management systems
Interactions play a fundamental role in distance education. The interactions occurring between learner and content; learner and learner; and learner and instructor are key interactions often studied in literature and have significant impact on academic ...
Yurdugül, Halil, Özgür, Adem
core
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
ASSESSMENT OF THE "MICRO-GREENNESS" OF SYNTHESES USING THE GREEN STAR
Rita C. C. Duarte +2 more
openaire +1 more source
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Development of validated methods for the simultaneous quantification of Finasteride and Tadalafil in newly launched FDA-approved therapeutic combination: greenness assessment using AGP, analytical eco-scale, and GAPI tools. [PDF]
Kammoun AK +3 more
europepmc +1 more source
Green stability-indicating RP-HPTLC technique for determining croconazole hydrochloride
Alam Prawez +7 more
doaj +1 more source
Stability-Indicating Spectrophotometric and TLC Densitometric Validated Methods for Simultaneous Assay of Salicylamide and Ascorbic Acid in the Presence of Salicylic Acid: Greenness Assessment and Practical Applicability. [PDF]
Al Kamaly O +7 more
europepmc +1 more source

