Results 31 to 40 of about 10,951 (139)

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

The Importance of Outcome Measures in the Management of Inflammatory Rheumatic Diseases

open access: yesOpen Access Rheumatology: Research and Reviews, 2021
Juan Molina Collada,1,2 Laura Trives,1 Isabel Castrejón1,2 1Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; 2Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, SpainCorrespondence: Isabel ...
Molina Collada J, Trives L, Castrejón I
doaj  

Regularization Approaches for High‐Dimensional Cox Models: A Case Study in Triple‐Negative Breast Cancer

open access: yesInternational Statistical Review, EarlyView.
Summary In high‐dimensional survival analysis, effective variable selection is crucial both for model interpretation and predictive performance. This paper investigates Cox regression with lasso and adaptive lasso penalties in genomic datasets where covariates far outnumber observations.
Pilar González‐Barquero   +2 more
wiley   +1 more source

La cuestión sociosanitaria en la obra de Marañón en el contexto de la lucha contra las enfermedades infecciosas

open access: yesAsclepio: Revista de Historia de la Medicina y de la Ciencia, 2011
Como es conocido, Gregorio Marañón y Posadillo (1887-1960), jugó un papel fundamental en el nacimiento de la Endocrinología en España. Sin embargo, su trabajo médico también se centró en otros importantes campos.
Antonio López Vega
doaj   +1 more source

Variability in Vascular Access Device Use, Dwell Time and Failure: Insights From Routine Nursing Documentation in a Multicentre Cohort Study

open access: yesJournal of Clinical Nursing, EarlyView.
ABSTRACT Aims To describe and compare institutional patterns of vascular access device use, dwell time, and failure, and to explore their implications for nursing practice. Design Retrospective multicentre observational cohort study. Methods Routinely collected nursing records of vascular access device insertion and removal were analysed from seven ...
Ismael Fernández‐Fernández   +8 more
wiley   +1 more source

El papel del profesional de Enfermería en los grupos multidisplinares de investigación en ciencias de la vida: Cuando no ser el primero también cuenta.

open access: yesNURE Investigación, 2006
Pascual Balsalobre, data manager del Servicio de Hematología del Hospital Gregorio Marañón y del Registro Europeo de Trasplante Hemopoyético, reflexiona sobre el papel de la Enfermería en los equipos multidisciplinares de investigación.
Pascual Balsalobre
doaj  

Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest

open access: yesScientific Reports, 2023
A secondary analysis of a randomized study was performed to study the relationship between volumetric capnography (VCAP) and arterial CO2 partial pressure (PCO2) during cardiopulmonary resuscitation (CPR) and to analyze the ability of these parameters to
Sara de la Mata Navazo   +18 more
doaj   +1 more source

Implementation of Obesity Interventions in Primary Health Care: Protocol for a Scoping Review of Barriers and Enablers

open access: yesObesity Reviews, EarlyView.
ABSTRACT Background Obesity is a major public health challenge worldwide, driving chronic disease and health care costs. Primary health care (PHC) is a key setting for prevention, early identification, and management of obesity, yet implementation of evidence‐based interventions remains limited.
Sandra León‐Herrera   +15 more
wiley   +1 more source

A Randomized Phase II Study of Subcutaneous Mosunetuzumab in Combination With Polatuzumab Vedotin Compared With Rituximab Plus Polatuzumab Vedotin in Patients With Relapsed or Refractory Large B‐Cell Lymphoma

open access: yesAmerican Journal of Hematology, Volume 101, Issue 9, Page 2177-2189, September 2026.
ABSTRACT Mosunetuzumab plus polatuzumab vedotin has shown promising activity versus rituximab plus polatuzumab vedotin (R‐Pola) in patients with relapsed/refractory (R/R) large B‐cell lymphoma (LBCL; NCT03671018). We present results from the Phase II randomized cohort, evaluating subcutaneous mosunetuzumab plus polatuzumab vedotin (Mosun‐Pola), with ...
Julio C. Chavez   +17 more
wiley   +1 more source

Criteria for Control and Remission of Respiratory Allergic Disease With Allergen Immunotherapy: A Delphi Consensus

open access: yesClinical and Translational Allergy, Volume 16, Issue 8, August 2026.
Expert consensus using a Delphi methodology proposed definitions of control and remission for allergic rhinitis, conjunctivitis and asthma in the context of allergen immunotherapy. These consensus‐based criteria integrate symptoms, medication use, patient‐reported outcomes and objective measures to support a more structured assessment of treatment ...
Eloína González‐Mancebo   +11 more
wiley   +1 more source

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