Results 21 to 30 of about 2,121 (149)

Effectiveness of Recombinant Human Growth Hormone Therapy in Small‐for‐Gestational‐Age Children With Short Stature: A Stratified Analysis Based on Genetic Variant Status

Clinical Endocrinology, Volume 105, Issue 5, Page 556-564, November 2026.
ABSTRACT Objective This study aimed to evaluate the impact of pathogenic genetic variants on growth outcomes following 3 years of recombinant human growth hormone (rhGH) therapy in children born small for gestational age with persistent short stature (SGA‐SS). Design A retrospective cohort study.
Sanghee Park, Yena Lee, Hwal Rim Jeong, Eun Young Kim, Eu‐seon Noh, Hye young Jin, Eun Byul Kwon, Hye Jin Lee, Young‐Jun Seo, Young Suk Shim, Su Jin Kim, Ji‐Eun Lee, Nan Young Kim, Sangkyoon Hong, Min Jae Kang, Il Tae Hwang   +15 more
wiley   +1 more source

Multidisciplinary Management of a Giant Ovarian Sertoli–Leydig Cell Tumor Presenting With Isosexual Precocious Puberty: A Pediatric Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Sertoli–Leydig cell tumors (SLCTs) are rare ovarian sex cord‐stromal tumors, particularly uncommon in the pediatric population. They are typically androgen‐secreting, while estrogen‐secreting forms are rare and may lead to diagnostic confusion with granulosa cell tumors.
Sanaa Bouramdane, Kenza Elmkaddem, Nawal Hammas, Meryem Boubbou, Othmane Alaoui, Khalid Khattala, Youssef Bouabdellah, Sarra Benmiloud   +7 more
wiley   +1 more source

Correlation of skeletal age by Greulich-Pyle atlas, physiological age by body development index, and dental age by London Atlas and modified Demirjian’s technique in children and adolescents of an Eastern Indian population

, 2023
Background Forensic age estimation using multiple maturity indicators necessitates investigation of correlation between various techniques. This study intended to compare and evaluate the correlation between skeletal age using Greulich-Pyle atlas, dental
Geeta Sahu, Gaurav Sharma, Champak Kumar Behera, Surya Narayan Das, Archana Bhatta, Rachna Rath   +5 more
core   +1 more source

Growth Hormone Treatment Response and Machine Learning‐Based Prediction in Idiopathic GHD and ISS: Analysis of the Korean LG Growth Study

Clinical Endocrinology, Volume 105, Issue 3, Page 322-330, September 2026.
ABSTRACT Objective Individual responses to recombinant human growth hormone (rhGH) therapy vary widely among children with idiopathic growth hormone deficiency (iGHD) and idiopathic short stature (ISS), making accurate prediction of treatment outcomes clinically important.
Jisun Park, Eun Young Joo, Su Jin Kim, Myung Ji Yoo, Ji Eun Lee   +4 more
wiley   +1 more source

External validation of the BABY‐Knee Algorithm for treatment decision‐making in skeletally immature patients with anterior cruciate ligament injuries: A Dutch cohort study

Journal of Experimental Orthopaedics, Volume 13, Issue 3, July 2026.
The external validation of the BABY‐Knee Algorithm showed inferior predictive performance compared with the original internal validation study in an Italian population, suggesting that the BABY‐Knee Algorithm is not directly applicable to other populations of skeletally immature patients with anterior cruciate ligament injuries.
Annika Babette Ito, Rob Paulus Augustinus Janssen, Stijn Thomas Henricus Croes, Robin Nicolaas Julian Voskuilen, Alberto Grassi, Maria Christine van der Steen, Martijn Dietvorst   +6 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Genotype–Phenotype Spectrum of Non‐Syndromic Monogenic Obesity in a National Paediatric Cohort

Pediatric Obesity, Volume 21, Issue 6, June 2026.
ABSTRACT Objective Non‐syndromic monogenic obesity, caused by defects in the leptin‐melanocortin pathway, presents with early‐onset severe obesity and hyperphagia, but genotype–phenotype and metabolic correlations across different genetic forms remain unclear.
Ahmet Kahveci, Selin Uzun Karauzum, Hayrullah Manyas, Behiye Sarikaya Ozdemir, Zerrin Orbak, Ummahan Tercan, Ruken Yildirim, Nihal Hatipoglu, Fatih Kilci, Hatice Nursoy, Servan Ozalkak, Baris Kolbasi, Semra Cetinkaya, Hazal Canbaz Ozdemir, Mesut Parlak, Filiz Tutunculer Kokenli, Emine Camtosun, Saime Ergen Dibeklioglu, Gonul Buyukyilmaz, Ayse Derya Bulus, Hanife Gul Balki, Ayse Ozden, E. Nazli Gonc, Elif Ozsu, Huseyin Demirbilek, Melek Yildiz, Samim Ozen, Abdullah Bereket, Belma Haliloglu   +28 more
wiley   +1 more source

Inteligencia Artificial vs Greulich Pyle : estudio comparativo para determinar la edad ósea entre niños normales y con sospecha de talla baja que acuden al Hospital Axxis, Quito-Ecuador, 2022

, 2022
Aim: To evaluate the concordance of a computer system based on Artificial Intelligence (AI) for determining bone age in children with respect to the Greulich-Pyle Method. Methods: A cross-sectional diagnostic test was carried out, in which a sample of
Calero Baquerizo, Juan José
core  

A novel MMP13 frameshift variant causes short stature via enhanced MMP13–HSPA5 interaction and activated endoplasmic reticulum stress

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The MMP13 R458fs protein is retained in the ER and exhibits enhanced binding to HSPA5, which promotes the dissociation of IRE1α, ATF6, and PERK. This triggers ER stress, leading to increased chondrocyte apoptosis and abnormal expansion of the growth plate hypertrophic zone, ultimately impairing long bone growth and causing short stature.
Huifei Lu, Xin Feng, Suping Dai, Yilin Zhu, Ke Yuan, Yonghua Chen, Jianfang Zhu, Yanlan Fang, Qingfeng Yan, Chunlin Wang   +9 more
wiley   +1 more source

The Metacarpophalangeal Pattern Profile: An Old Method With New Insights Into the Evaluation of Short Stature

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objective To characterize the metacarpophalangeal pattern profile (MCPP) of healthy children and adolescents from São Paulo, Brazil, and to establish percentile curves by chronological age (CA), bone age (BA), and sex using the LMS method. Additionally, to compare these findings with previous population‐based data and to apply the derived ...
Marcelo Damaso Maruichi, Bruno Telma Destailleur, Giulia Maesta Apelbaum, Carlos Alberto Longui, Cristiane Kochi   +4 more
wiley   +1 more source