Results 61 to 70 of about 1,155,403 (295)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Artificial Intelligence Techniques in Smart Grid: A Survey

Smart Cities, 2021
The smart grid is enabling the collection of massive amounts of high-dimensional and multi-type data about the electric power grid operations, by integrating advanced metering infrastructure, control technologies, and communication technologies. However,
O. Omitaomu, Haoran Niu
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Where, how, and how much? A multicenter cohort study of the relationship between lupus decision aid modality, place of administration, interruption and viewing completeness and patient‐reported outcomes

Arthritis Care &Research, Accepted Article.
Objective We assessed whether shared decision‐making (SDM), and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE), differs by PtDA setting, modality, and the viewing experience.
Jasvinder A. Singh, Mark Beasley, Larry R. Hearld, for the Implementing DEcision‐Aid for Lupus in clinics (IDEAL) Consortium   +3 more
wiley   +1 more source

Grid-Forming Inverters: A Critical Asset for the Power Grid

IEEE Journal of Emerging and Selected Topics in Power Electronics, 2020
Increasing inverter-based sources reduces the system’s inertia resulting in possible frequency stability issues. Understanding low-inertia systems and their stability properties is of crucial importance.
R. Lasseter, Zhe Chen, Dinesh Pattabiraman   +2 more
semanticscholar   +1 more source

Techno-Economic-Environmental Assessment of Stand-alone Hybrid Renewable Energy System for Different Batteries using HOMER-Pro [PDF]

International Journal of Mathematical, Engineering and Management Sciences
The whole world is now widely using green energy compared to fossil because of the depletion of fossil fuels, the rising temperature of the earth, and changing weather conditions, all these things are becoming a big threat to the life of the earth.
Abhishek Solanki, Poonam Singh, Manjaree Pandit, Yashwant Sawle, Majed A. Alotaibi, Hasmat Malik, Fausto Pedro García Márquez, Asyraf Afthanorhan   +7 more
doaj   +1 more source

Networked Microgrids for Grid Resilience, Robustness, and Efficiency: A Review

IEEE Transactions on Smart Grid, 2021
Networked microgrids (NMGs) are clusters of microgrids that are physically connected and functionally interoperable. The massive and unprecedented deployment of smart grid technologies, new business models, and involvement of new stakeholders enable NMGs
Bo Chen, Jianhui Wang, Xiaonan Lu, Chen Chen, Shijia Zhao   +4 more
semanticscholar   +1 more source

MULTIAGENT METHODS OF MANAGEMENT OF DISTRIBUTED COMPUTING IN HYBRID CLUSTERS

Сучасні інформаційні системи, 2022
Modern information technologies include the use of server systems, virtualization technologies, communication tools for distributed computing and development of software and hardware solutions of data processing and storage centers, the most effective of
Vadim Kolumbet, Olha Svynchuk
doaj   +1 more source