Results 151 to 160 of about 154,734 (260)

Mortality in narcolepsy and other sleep clinic patients: a 25-year propensity-matched VA cohort study. [PDF]

J Clin Sleep Med
Sharafkhaneh A, Dauvilliers Y, BaHammam AS, Azarian M, Thorpy M, Han F, Senel GB, Aksu M, Razjouyan J.   +8 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

A long-term ecosystem monitoring dataset from the ICP Integrated Monitoring network: biogeochemical data from 1977-2020 across 14 European countries. [PDF]

Sci Data
Weldon J, Aas W, Albiniak B, Augustaitis A, Baužienė I, Capelli C, Clarke N, Cummins T, de Wit HA, Dirnböck T, Djukic I, Eklöf K, Forsius M, Futter M, Grandin U, Gromov S, Šmejkalová AH, Ibañez R, Indriksone I, Jutterström S, Kobler J, Koger H, Kölbl A, Kostrzewski A, Koukhta A, Krám P, Kruszyk R, Lasheras E, Lõhmus K, Majewski M, Makkonen U, Markensten H, Miranda R, Mirtl M, Moldan F, Papitto G, Peterseil J, Pivoras A, Plha T, Pröll G, Rönnback P, Santamaría C, Santamaría JM, Skotak K, Elustondo D, Valerio M, Venier S, Vlaar LE, Ukonmaanaho L, Vuorenmaa J, Wellbrock N.   +50 more
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Representation learning to advance multi-institutional studies with electronic health record data from US and France. [PDF]

Nat Commun
Zhou D, Tong H, Wang L, Liu S, Xiong X, Gan Z, Romain G, Hejblum BP, Liu YC, Hong C, Bonzel CL, Cai T, Pan K, Ho YL, Costa L, A Panickan V, Gaziano JM, Mandl KD, Jouhet V, Thiebaut R, Xia Z, Cho K, Liao K, Cai T.   +23 more
europepmc   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

A distributed analysis approach for pharmacovigilance data from electronic medical records in German university hospitals: the POLAR_MI ETL Pipeline. [PDF]

BMC Med Inform Decis Mak
Kesselmeier M, Thalheim T, Schmidt F, Peschel T, Palm J, Strübing A, Medek A, Przybilla J, Wermund AM, Maas R, Härterich S, Redeker L, Federbusch M, Steinbach D, Gewehr J, Wurlitzer M, Riedel A, Meineke F, Neumann D, Scherag A, Loeffler M, POLAR_MI.   +21 more
europepmc   +1 more source

Photonic Time Crystals and Time‐Varying Electromagnetic Metamatter: A New Direction for Ultrafast Tunable Photonic and Microwave Materials and Devices

Advanced Science, EarlyView.
Photonic time crystals (PTCs) are systems in which electromagnetic parameters are modulated periodically in time, producing momentum bandgaps via temporal scattering rather than spatial Bragg processes. This review examines the theoretical frameworks, modeling, and computational tools for time‐varying media, and summarizes experimental demonstrations ...
Ranjan Kumar Patel, Shriram Ramanathan, Ronald P. Jenkins, Michael J. Carter   +3 more
wiley   +1 more source

Perinatal mental health research: priorities from a neurodiverse sample in the United Kingdom. [PDF]

Arch Womens Ment Health
Lautarescu A, Heraty S, Johnson C, Ruigrok A, Eaton E, Bazelmans T, Sigurdardottir J, Ratti V, Stone H, Anderson J, Javed A, Mahtani S, Lau-Zhu A, Smith DM.   +13 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source