Results 191 to 200 of about 348,888 (311)

Potentialities of Grid Search Method [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2000
openaire   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Supporting Formation and Operation of Virtual Organisations in a Grid Environment

, 2004
The ability to create reliable and scalable virtual organisations (VOs) on demand in a dynamic, open and competitive environment is one of the challenges that underlie the Grid concept and research.
Michael Luck, Fiddian, N. J., Simon Thompson, Preece, A., Nguyen, T.D., Nir Oren, Chalmers, S, Dang, V. D, Jennings, NR, Teacy, WTL, Preece, Alun David, Stockreisser, PJ, Gray, PMD, Gray, William Alexander, Deora, V, Nick J Fiddian, Peter M D Gray, Nguyen, TD, Luck, M.; id_orcid, W T Luke Teacy, Norman, T. J., Stockreisser, Patrick J., Shao, J, Gray, W. A., Oren, N, Chalmers, S., Dang, VD, Shao, J., Luck, M., Stockreisser, P. J., Viet D Dang, Stockreisser, P.J., Shercliff, G., Gray, P. M. D., Gray, W.A., Fiddian, Nicholas John, Teacy, W. T. L, Teacy, W. T. L., Luck, M, Nicholas R Jennings, Preece, A, Deora, Vikas, Nguyen, T. D., Jennings, N. R., Teacy, W.T.L., Fiddian, N.J, Shercliff, Gareth, W Alex Gray, Stuart Chalmers, Norman, T.J., Norman, Timothy, Jianhua Shao, Timothy J Norman, Dang, V.D., Patel, J, Patrick J Stockreisser, Shao, Jianhua, Deora, V., Patel, J., Gareth Shercliff, Jigar Patel, Norman, TJ, Vikas Deora, Gray, P.M.D., Fiddian, NJ, Alun Preece, Shercliff, G, Thuc D Nguyen, Gray, WA, Oren, N.   +69 more
core  

Distributed denial of service (DDoS) classification based on random forest model with backward elimination algorithm and grid search algorithm. [PDF]

Sci Rep
Sawah MS, Elmannai H, El-Bary AA, Lotfy K, Sheta OE.   +4 more
europepmc   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Enhanced skin cancer diagnosis through grid search algorithm-optimized deep learning models for skin lesion analysis. [PDF]

Front Med (Lausanne)
Pillai R, Sharma N, Gupta S, Gupta D, Juneja S, Malik S, Qin H, Alqahtani MS, Ksibi A.   +8 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Towards the semantic grid: enriching content for management and reuse

, 2003
Knowledge and Semantic Web technologies are evolving the Grid towards the Semantic Grid [18] to facilitate knowledge reuse and collaboration within a community of practice.
Song, W, Cox, S.J., Xu, Fenglian, Shadbolt, Nigel, Cox, Simon, Xu, F., Puleston, C., Shadbolt, N., Chen, Liming, Goble, Carole, Song, Wenbin, Tao, F., Tao, Feng, Goble, C., Puleston, Colin   +14 more
core  

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Prediction of major adverse cardiac events in the emergency department using an artificial neural network with a systematic grid search. [PDF]

Int J Emerg Med
Raheem A, Waheed S, Karim M, Khan NU, Jawed R.   +4 more
europepmc   +1 more source