Results 161 to 170 of about 152,143 (294)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Author Correction: NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. [PDF]

Cell Mol Immunol
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H.   +19 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

An Innovative Semiparametric Density Model for the Statistical Characterization of Ground-Vehicle Radar Cross Sections. [PDF]

Sensors (Basel)
Liu Z, Wen S, Sun H, Deng M.
europepmc   +1 more source

Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics

Advanced Science, EarlyView.
This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley   +1 more source

MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBC. [PDF]

J Mol Med (Berl)
Tseng LM, Lau KY, Chen JL, Chu PY, Huang CT, Wang WL, Chang YY, Lai JI, Huang CC, Dai MS, Liu CY.   +10 more
europepmc   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

An optimization framework for battery health management in vehicle-to-grid systems integrating transformer-based degradation prediction and grid service requirements. [PDF]

Sci Rep
Zhong C, Ma Q, Ren M, Xiong L.
europepmc   +1 more source

Breaking the Kinetics–Loading Trade‐Off in Zinc‐Ion Hybrid Capacitors Through Synergistic Electron–Ion Transport Design

Advanced Science, EarlyView.
High‐mass‐loading carbon cathodes are essential for practical zinc‐ion hybrid capacitors but suffer from severe transport limitations. By combining low‐tortuosity freeze‐dried pore channels with carbon nanotube conductive networks, simultaneous optimization of ion and electron transport is achieved, enabling high‐rate, long‐life pouch cells and ...
Jiacheng Wu, Yangyang Wang, Fangzhou Liu, Fangxin She, Justin Prabowo, Di Zhu, Xin Yang, Li Wei, Yuan Chen   +8 more
wiley   +1 more source

Bounding the costs of electric vehicle managed charging-supply curves for scenarios from 2025 to 2050. [PDF]

Sci Data
Matsuda-Dunn R, Hale E, Estreich E, Lavin L, Konar-Steenberg G.   +4 more
europepmc   +1 more source