Results 51 to 60 of about 283,862 (317)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

alisterburt/torch-cubic-spline-grids: v0.0.4

open access: yes, 2023
<h2>What's Changed</h2> <ul> <li>add support for interpolating on grids with Catmull-Rom splines by @alisterburt in https://github.com/alisterburt/torch-cubic-spline-grids/pull/9</li> <li>Rename package to accommodate ...
alisterburt
core   +1 more source

Scintillating Grid Illusion Without the Grid [PDF]

open access: yesi-Perception, 2020
The scintillating grid illusion is a phenomenon where illusory black spots are perceived on white patches located at the intersections of a grid pattern. In this study, I report that the illusory spots as observed in the illusion are perceived with a stimulus pattern without grid bars. In two experiments, I investigated the perceptual properties of the
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Decoupled overlapping grids for the numerical modeling of oil wells

open access: yes, 2012
Accurate computation of time-dependent well bore pressure is important in well test analysis - a branch of petroleum engineering where reservoir properties are estimated by comparing measured pressure responses at an oil well to results from a ...
Dugald B. Duncan   +3 more
core   +1 more source

Parallel Processing of Images in Mobile Devices using BOINC

open access: yesOpen Engineering, 2018
Medical image processing helps health professionals make decisions for the diagnosis and treatment of patients. Since some algorithms for processing images require substantial amounts of resources, one could take advantage of distributed or parallel ...
Curiel Mariela   +4 more
doaj   +1 more source

Grid Characteristics and Uses: A Grid Definition [PDF]

open access: yes, 2004
This paper discusses the concept of grid towards achieving a complete definition using main grid characteristics and uses found in literature. Ten definitions extracted from main literature sources have been studied allowing the extraction of grid characteristics while grid uses are defined in terms of the different types of application support ...
Miguel L. Bote-Lorenzo   +2 more
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Grid-Forming Converters for Stability Issues in Future Power Grids

open access: yes, 2022
Historically, the power system has relied on synchronous generators (SGs) to provide inertia and maintain grid stability. However, because of the increased integration of power-electronics-interfaced renewable energy sources, the grid’s stability ...
Shahid Aziz Khan   +4 more
core   +1 more source

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