Results 231 to 240 of about 304,255 (309)

Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu   +4 more
wiley   +1 more source

Highly Efficient Mechanochromic Thermally Activated Delayed Fluorescence in the Deep Red to Near‐Infrared in Copper(I) [2.2]Isoindolinophanyl‐Carbene Carbazolates

open access: yesAngewandte Chemie, EarlyView.
Electrophilic [2.2]isoindolinophanyl‐based carbene iPC has been employed as charge‐transfer acceptor ligand in a series of [Cu(iPC)(carbazolate)], which show mechanochromism and environment‐dependent luminescence due to intermolecular C─‐H‐π interactions.
André M. T. Muthig   +10 more
wiley   +2 more sources

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao   +5 more
wiley   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li   +6 more
wiley   +1 more source

Dynamic Covalent Radical Recombination for the Assembly of Tuneable Responsive Porous Organic Cages

open access: yesAngewandte Chemie International Edition, EarlyView.
Dynamic covalent chemistry (DCC) based on reversible radical recombination enables the assembly of responsive, C─C‐linked organic cages. Substituent‐controlled aryldicyanomethyl radicals form discrete, porous architectures with tuneable topology of Tri2 and Tri4 cages, gas selectivity, chromism, and self‐healing behaviour, establishing radical‐based ...
Yannic Hartmann   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy