Results 31 to 40 of about 79,585 (312)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Effect of static wrist position on grip strength

Indian Journal of Plastic Surgery, 2011
Background: Grip strength after wrist arthrodesis is reported to be significantly less than normal. One of the reasons suggested for this decrease in grip strength is that the arthrodesis was performed in a suboptimal position.
Praveen Bhardwaj, Saumyakumar S. Nayak, Asif M. Kiswar, S. Raja Sabapathy   +3 more
doaj   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort

BMC Geriatrics, 2021
Background Grip strength is an indicator of physical function with potential predictive value for health in ageing populations. We assessed whether trends in grip strength from midlife predicted later-life brain health and cognition.
Quentin Dercon, Jennifer M. Nicholas, Sarah-Naomi James, Jonathan M. Schott, Marcus Richards   +4 more
doaj   +1 more source

Weak Hand Grip Strength Is Associated with Alexithymia in Outpatients in a Mexican Population

Brain Sciences, 2022
Hand grip strength has been considered as a possible marker for metabolic and psychiatric disease. To date, however, no research has focused on the association between alexithymia and hand grip strength.
Alma Delia Genis-Mendoza, Ana Fresán, Thelma Beatriz González-Castro, Sherezada Pool-García, Carlos Alfonso Tovilla-Zárate, Rosa Giannina Castillo-Avila, Pedro Iván Arias-Vázquez, María Lilia López-Narváez, Humberto Nicolini   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of the sport intervention effect on the grip strength of workers exposed to hand-arm vibration

Muhandisī-i bihdāsht-i ḥirfah/ī, 2021
Introduction: Grip strength is one of the important parameters in hand muscle function that vibration can have a negative effect on it. The aim of this study was to determine of the sport intervention effect on the grip strength of workers exposed to ...
Behnam Moradi, Javad Azadi, Samira Barakat   +2 more
doaj  

Grip strength, body composition, and mortality [PDF]

International Journal of Epidemiology, 2006
Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle mass and an increase in fat, but the role that body composition plays in the association between grip strength and mortality has been little explored.
Gale, Catharine R., Martyn, Christopher N., Cooper, Cyrus, Sayer, Avan Aihie   +3 more
openaire   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Anthropometry based prediction of dominant hand grip strength in Indian office going females

Asian Journal of Medical Sciences, 2016
Background: Physical strength can be measured by means of hand grip strength. It is of great use as a functional index of nutritional status. Aims and Objectives: Physical strength can be measured by means of hand grip strength.
S Rawat
doaj   +1 more source