Results 41 to 50 of about 13,489 (291)

COVID-19, la grippe et les ­syndromes grippaux

, 2020
L'épidémie de «grippe» de l'hiver 2020/2021 sera un défi pour les médecins généralistes et les médecins des hôpitaux. La COVID-19 ne peut pas être cliniquement distinguée de la grippe et d'autres syndromes grippaux – le diagnostic différentiel le plus ...
Tolic, Josipa, Wingeier, Bernhard, Hausmann, Oliver, Dietrich, Léna, Romer, Tobias, Rasch, Helmut, Ernst, Thomas, Béguelin, Charles, Rllin, Alexandra, Huber, Benedikt, Schb, Lukas, Wirz, Sebastian, Gallmann, Caesar, Frhlich, Jrg, Flury, Domenica, Providoli, Romeo, Meynard-Colomb, Anne, Hasse, Barbara, Suggs, Suzanne, Deml, Michael, Schmid-Thurneysen, Lisa, Etter, Gisela, Tarr, Philip E., Seyam, Muhannad, Kovari, Helen, Abreu De Azevedo, Marta, Busche, Philipp, Jusufoska, Meliha, Michael J. Deml, Anne Meynard, Philipp Busche, Oliver Hausmann, Philip Tarr, Tobias Romer, Domenica Flury, Tarr, Philip, Barbara Hasse, Lukas Schöb, Gisela Etter, Charles Béguelin, Benedikt Huber, Muhannad Seyam, Caesar Gallmann, Suzanne Suggs, Meliha Jusufoska, Josipa Tolic, Bguelin, Charles, Helmut Rasch, Meynard, Anne, Deml, Michael J., Jürg Fröhlich, Alexandra Röllin, Dietrich, Lna, Sebastian Wirz, Helen Kovari, Léna Dietrich, Bernhard Wingeier, Thomas Ernst, Lisa Schmid-Thurneysen, Marta Abreu De Azevedo, Romeo Providoli, Jrg Frhlich, Alexandra Rllin, Michael J. Deml, Charles Bguelin, Lukas Schb, Lna Dietrich   +66 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Grippe

PrimaryCare, 2007
S. Bouvresse, F. Bricaire, P. Bossi
  +7 more sources

La méningite « prise en grippe » ?

Anthropologie & Santé, 2012
The control of public health issues in Niger requires obeying the requirements of the international institutions for health. While we might expect that such requirements are practical, they also construct the representation of epidemic risk.
Oumy Thiongane
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Une approche communautaire à l'évaluation et au traitement d'une grippe pandémique

, 2007
Dans le cas d'une pandémie de grippe, les hôpitaux et les services de santé communautaires seront surchargés. Afin d'assurer que les services de santé d'importance vitale soient en mesure de poursuivre leur travail, le Plan ontarien de lutte contre la ...
Phil Graham, Mark J. Breen, Allison J. Stuart   +2 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source