Results 161 to 170 of about 4,151 (197)

Distinct Phosphorylation Patterns of AT1R by Biased Ligands and GRK Subtypes

International Journal of Molecular Sciences
G protein-coupled receptors (GPCRs) transmit through G proteins upon agonist activation, followed by phosphorylation by GPCR kinases (GRKs) to initiate β-arrestin signaling. However, the molecular mechanisms underlying GPCR signaling regulation by distinct agonists, GRK subtypes, and phosphorylation patterns remain poorly understood. The angiotensin II
Jingyuan Li, Haitao Zhang
exaly   +4 more sources

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GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling

Trends in Endocrinology & Metabolism, 2006
Stimulation of cell-surface seven-transmembrane receptors (7TMRs) elicits biological responses to a wide range of extracellular signals, including many hormones. Classically, heterotrimeric GTP-binding proteins (G proteins) are recruited to the activated conformation of 7TMRs.
Reiter, Eric, Lefkowitz, J.
openaire   +2 more sources

[GRKs and arrestins: the therapeutic pathway?].

Medecine sciences : M/S, 2006
Phosphorylation of the agonist-activated form of G-protein-coupled receptors (GPCRs) by a protein kinase from the G-protein-coupled receptor kinase (GRK) family initiates, with arrestin proteins, a negative feedback process known as desensitization.
Thierry, Métayé, Rémy, Perdrisot, Jean-Louis, Kraimps   +2 more
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GRK Gatekeeper of pain and inflammation

2009
More then 10% of the population suffers from chronic pain. Treatment often fails since individual susceptibility is highly variable. Therefore, better understanding of factors involved in determination whether pain becomes chronic is crucial. In this thesis we investigated the role of two kinases, G protein-coupled receptor kinase (GRK) 2 and 6, as ...
Eijkelkamp, N., Infection & Immunity, DDOD, Heijnen, J.J., Kavelaars, AMAA   +4 more
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Zaštita geografskog podrijetla kvalitetnog vina "Grk"

1982
U elaboratu su prikazani rezultati zaštite geografskog podrijetla kvalitetnog vina "Grk"
Pezo, Ivan, Maleš, Petar
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Frontiers in Cell and Developmental Biology, 2021
Julia Drube, Raphael Silvanus Haider, Edda Matthees   +2 more
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Unaprjeđenje tehnologije proizvodnje grožđa cv. Grk

2010
Rad sadržava pregled stanja tla u vinogradima i ishranjenost vinove loze cv. Grk, utvrđivanje zdravstvenog stanja te bioloških i gospodarskih karaketristika cv. Grk.
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Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport

Journal of Biological Chemistry, 2021
Sofie Bach, Tatyana Mamonova, Peter A Friedman   +2 more
exaly  

GRKs

2006
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Conformational changes in histone GRK (f2a1)

Biochemistry, 1974
M J, Smerdon, I, Isenberg
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