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Het Ontwerp-Gemeenschappelijk Referentiekader (GRK) voor een Europees privaatrecht
WPNR: Weekblad voor privaatrecht, notariaat en registratie, 2008 openaire +2 more sources
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GPCR signalling in hypertension: role of GRKs
Clinical Science, 2008Hypertension is a prevalent condition in the developed world and disease severity is directly correlated with additional cardiovascular complications. It is estimated that 30% of the adult population in the United States has hypertension, which is classified as a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg.
David M, Harris +3 more
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Science Signaling, 2009
Hedgehog promotes the interaction of G protein–coupled receptor kinase with Patched, releasing cyclin B1 to stimulate cell proliferation.
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Hedgehog promotes the interaction of G protein–coupled receptor kinase with Patched, releasing cyclin B1 to stimulate cell proliferation.
openaire +1 more source
Science Signaling, 2008
G protein-coupled receptor kinase 5 (GRK5) phosphorylates HDAC5, thus allowing the transcription of genes involved in cardiac hypertrophy.
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G protein-coupled receptor kinase 5 (GRK5) phosphorylates HDAC5, thus allowing the transcription of genes involved in cardiac hypertrophy.
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Regulation of Receptor Trafficking by GRKs and Arrestins
Annual Review of Physiology, 2007To ensure that extracellular stimuli are translated into intracellular signals of appropriate magnitude and specificity, most signaling cascades are tightly regulated. One of the major mechanisms involved in the regulation of G protein–coupled receptors (GPCRs) involves their endocytic trafficking.
Catherine A C, Moore +2 more
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Science Signaling, 2018
The dopamine D2 receptor recruits and activates the kinase GRK2 without the need for G protein activation.
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The dopamine D2 receptor recruits and activates the kinase GRK2 without the need for G protein activation.
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The effect of temperature on histone GRK aggregation
Biochemical and Biophysical Research Communications, 1973Abstract The aggregation of histone GRK, induced by the addition of salt, is found to be highly dependent on temperature. The rate of this aggregation decreases with decreasing temperature and can be essentially stopped at low temperatures.
M J, Smerdon, I, Isenberg
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[GRKs and arrestins: the therapeutic pathway?].
Medecine sciences : M/S, 2006Phosphorylation of the agonist-activated form of G-protein-coupled receptors (GPCRs) by a protein kinase from the G-protein-coupled receptor kinase (GRK) family initiates, with arrestin proteins, a negative feedback process known as desensitization.
Thierry, Métayé +2 more
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