Results 291 to 300 of about 60,004 (331)

Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion. [PDF]

Nat Commun
Zhang H, Shang R, Zhang Z, Zhou M, Bigot A, Cai Y, Zhao Y, Wang Y, Deshmukh A, Kudryashova E, Kudryashov DS, He C, Mouly V, Bi P.   +13 more
europepmc   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers. [PDF]

Cell Death Dis
Zhang W, Lin J, Zhou Y, Wu C, Li Q, Chen J, Zeng Y, Xiao Z, Shen H, Wu Y, Su Z, Yu W, Xie Z.   +12 more
europepmc   +1 more source

Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a complex syndrome marked by weight loss and muscle wasting, significantly impacting patient quality of life and survival. Mechanistically, it is characterized by suppressed protein synthesis and enhanced muscle catabolism, with the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR ...
Yusaku Kaneko, Tomohiro Hino, Shunta Taminishi, Yayoi Matoba, Daisuke Motooka, Atsushi Hoshino, Satoaki Matoba   +6 more
wiley   +1 more source

CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement

Plant-Environment Interactions, Volume 7, Issue 2, April 2026.
ABSTRACT CRISPR/Cas‐based genome editing has emerged as a transformative tool for precise genetic improvement of cereal crops. Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain ...
Sirisha Kaniganti, Himanshu Saini, A. K. Chaitanya, Niranjan Hegde, Priya Shah, Nakul D. Magar, Ramesh Rijal, Jeevan Jyoti Kaushik, Deepak Nanda, Sharad Sachan, Anand Kumar, Roopali Bhoite, Harsha Rayudu Jamedar   +12 more
wiley   +1 more source

Argonaute-mediated RNA editing selectively repairs point mutations. [PDF]

Nucleic Acids Res
Zhang Z, Wang J, Guo T, Yu X, Wang F, Zhang H, Liu Y, Li W, Cheng Y, Peng Y, Yan G, Cui J, Ma L.   +12 more
europepmc   +1 more source

Development and Laboratory Validation of a Field‐Deployable CRISPR‐Cas12a eDNA Assay for Phylogeographic Lineage Detection in Arctic Char (Salvelinus alpinus)

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Environmental DNA (eDNA) tools are increasingly used for biodiversity monitoring, with most existing assays targeting species‐level identification. However, the use of eDNA to resolve intraspecific genetic variation remains rare and methodologically underdeveloped.
Darren J. Walsh, Rosaleen Hynes, Weili Guo, Cliodhna Surgenor, Paulo A. Prodöhl, Anne Parle‐McDermott   +5 more
wiley   +1 more source

One-pot recombinase polymerase amplification and CRISPR/Cas12a assay for Cryptococcus neoformans. [PDF]

Appl Microbiol Biotechnol
Li Z, Chen L, Luo J, Lu Y, Zhang H, Zhao P.   +5 more
europepmc   +1 more source