Results 11 to 20 of about 1,337 (150)

Stathmin-2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1-6 cells. [PDF]

J Physiol
Abstract figure legend Paracrine regulation of glucagon involves Stathmin2‐mediated trafficking of glucagon through lysosomal transport. Glucagon secretion is regulated by the paracrine hormones insulin and somatostatin. We postulate that insulin enhances lysosomal transport of glucagon away from sites of exocytosis, and somatostatin functions in the ...
Chang N, Ugulini S, Dhanvantari S.
europepmc   +2 more sources

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes [PDF]

Aging Cell
Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Tudurí E, Almagro L, Ojeda‐Rodríguez A, Pascua‐Maestro R, Brunetta H, Soriano S, López‐Moreno A, Boronat‐Belda T, Velasco‐Avilés S, da Silva Junior J, Castellano‐Muñoz M, Rafacho A, Cózar‐Castellano I, Nadal Á, Alonso‐Magdalena P, Merino B, López‐Miranda J, Quesada I.   +17 more
europepmc   +2 more sources

Luseogliflozin restores GIP responsiveness in diabetic male mice with preserved β-cell function. [PDF]

Physiol Rep
Abstract Impaired glucose‐dependent insulinotropic polypeptide (GIP)‐induced insulin secretion is a characteristic feature of type 2 diabetes, whereas glucagon‐like peptide‐1 (GLP‐1) responsiveness is relatively preserved. Our previous study proposed that chronic β‐cell depolarization alters G protein signaling and contributes to this differential ...
Yingyue Q, Takahashi H, Yokoi N, Ogawa W, Sugawara K.   +4 more
europepmc   +2 more sources

Determining UAV Flight Trajectory for Target Recognition Using EO/IR and SAR [PDF]

Sensors, 2020
The paper presents the concept of planning the optimal trajectory of fixed-wing unmanned aerial vehicle (UAV) of a short-range tactical class, whose task is to recognize a set of ground objects as a part of a reconnaissance mission.
Wojciech Stecz, Krzysztof Gromada
doaj   +2 more sources

Real-Time Object Detection and Classification by UAV Equipped With SAR [PDF]

Sensors, 2022
The article presents real-time object detection and classification methods by unmanned aerial vehicles (UAVs) equipped with a synthetic aperture radar (SAR).
Krzysztof Gromada, Barbara Siemiątkowska, Wojciech Stecz, Krystian Płochocki, Karol Woźniak   +4 more
doaj   +2 more sources

Somatostatin modulation of initial fusion pores in Ca²⁺-triggered exocytosis from mouse chromaffin cells. [PDF]

J Physiol
Abstract figure legend Somatostatin binds to a G‐protein‐coupled receptor to inhibit the release of catecholamine from chromaffin cells. This action has no impact on Ca2+ levels and is similar for Ca2+ entry through voltage‐gated Ca2 channels and for Ca2+ mobilization from the endoplasmic reticulum.
Cheng J, Jackson MB.
europepmc   +2 more sources

UAV Mission Planning with SAR Application [PDF]

Sensors, 2020
The paper presents the concept of mission planning for a short-range tactical class Unmanned Aerial Vehicle (UAV) that recognizes targets using the sensors it has been equipped with.
Wojciech Stecz, Krzysztof Gromada
doaj   +2 more sources

A New Lens on Childhood Obesity: Developing and Validating the Obesity-Related Well-Being (ORWB) Scale for Assessing Well-Being in Obese Children and Adolescents. [PDF]

J Obes
The increasing prevalence of pediatric obesity is a significant public health issue, with conventional diagnostic methods often overlooking its psychological, social, and lifestyle consequences. This study aimed to create and confirm the validity of the obesity‐related well‐being (ORWB) scale, a new tool designed to evaluate the diverse impacts of ...
Faleh J, Dergaa I, Ceylan Hİ, Ghouili H, Guelmami N, Jahrami H, Trabelsi K, Ben Aissa M, Zghibi M, Muntean RI, Ammar A.   +10 more
europepmc   +2 more sources

Track Differences in Civic and Democratic Engagement During Secondary Education: A New Panel Study From the Netherlands. [PDF]

Br J Sociol
ABSTRACT Whether students educated in different ability tracks in secondary education develop different levels of civic and democratic engagement is yet unclear. To explore this issue, we focus on how schools bring students of different tracks and family backgrounds together, and whether such between‐school differences are associated with varying ...
van de Werfhorst H, Ten Dam G, Geven S, Huijsmans T, Mennes H, Mulder L, van Slageren J, van der Meer T.   +7 more
europepmc   +2 more sources

Mutagenesis and Adaptation of the Psychrotrophic Fungus Chrysosporium pannorum A-1 as a Method for Improving β-pinene Bioconversion [PDF]

Molecules, 2020
Mutagenesis and adaptation of the psychrotrophic fungus Chrysosporium pannorum A-1 to the toxic substrate β-pinene were used to obtain a biocatalyst with increased resistance to this terpene and improved bioconversion properties.
Mateusz Kutyła, Jan Fiedurek, Anna Gromada, Krzysztof Jędrzejewski, Mariusz Trytek   +4 more
doaj   +2 more sources