Results 21 to 30 of about 2,432 (198)

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Mutations de l'encépagement et politiques de qualité dans les vignobles provençaux, XIXe-XXIe siècles.

Territoires du Vin, 2019
Le vignoble provençal a connu, comme ses homologues français, d'importantes mutations depuis la crise phylloxérique. La production, dominée par des vins courants, notamment des rouges, est marquée à partir des années 1950, par une progression ...
Frédéric Moustier, Philippe Moustier
doaj   +1 more source

Animal empathy reconsidered: a multidimensional profile account

Biological Reviews, EarlyView.
ABSTRACT Empathy is the glue that holds societies together and yet several fundamental questions about empathy persist. What is empathy (the definitional question)? Is it uniquely human and, if not, which nonhuman animals possess empathy (the distribution question)? Which type or quality of empathy is realized in different species (the quality question)
Albert Newen, Maja Griem, Ludwig Huber, Thomas Bugnyar, Aaron Blaisdell, Simone Pika   +5 more
wiley   +1 more source

La sociodidactique des langues, ses origines et ses acquis : un parcours de trente ans de recherches

Didactiques & Disciplines
Cette contribution présente le courant de sociodidactique des langues, ses origines scientifiques et institutionnelles interdisciplinaires, sa diffusion et ses acquis.
Philippe Blanchet Lunati, Marielle Rispail   +1 more
doaj   +1 more source

Avant-propos

INRAE Productions Animales, 2009
L’Agriculture Biologique (AB) se présente comme un mode de production agricole spécifique basé sur le respect d’un certain nombre de principes et de pratiques visant à réduire au maximum les impacts négatifs sur l’environnement.
H. GUYOMARD, B. COUDURIER, P. HERPIN
doaj   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

Introduction au numéro hors série Encéphalopathies spongiformes transmissibles animales

INRAE Productions Animales, 2004
Les agents des encéphalopathies spongiformes transmissibles (ESST) sont responsables de maladies neurodégénératives fatales chez l’homme (maladie de Creutzfeldt-Jakob, insomnie fatale familiale, syndrome de Gerstmann-Straussler-Scheinker, Kuru) et chez ...
J.M. ELSEN, J.M. AYNAUD
doaj   +1 more source

A Co‐Designed Implicit‐Reset Path PFD and Current Mismatch Compensated CP Enabling Sub‐0.5% Mismatch and Dead Zone‐Free for Low‐Spur PLLs

International Journal of Circuit Theory and Applications, EarlyView.
A co‐designed implicit‐reset phase‐frequency detector (PFD) and nonlinear amplifier‐assisted charge pump (CP) achieve dead zone‐free operation from 10 MHz to 4.7 GHz with < 0.5% current mismatch without calibration, enabling −80 dBc of reference spur and 0.50 ps of RMS jitter in a 180 nm of CMOS PLL.
A. Ghaemnia, Jincheng Yang, Xiaojiong Fei, G. Zhang   +3 more
wiley   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Zoom on Electricity | Gros plan sur l’électricité

Revue Internationale De Politique De Développement, 2011
exaly   +3 more sources