Results 61 to 70 of about 9,908,808 (335)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Steep uphill cycling using repeated transitions between seated and standing positions results in a lower blood-lactate concentration than continuous use of either seated or standing position

Frontiers in Sports and Active Living
This study investigated whether repeated transitions between seated and standing positions has a different physiological response compared to continuous use of either seated position or standing position during steep uphill cycling among elite cyclists ...
Magnus Carlsson, Oliver Lindblom, Tomas Carlsson   +2 more
doaj   +1 more source

CONTRIBUTION OF SUBSIDIES TO THE LEVEL OF INCOME OF SMALL FARMS IN BULGARIA [PDF]

Journal of Bio-Based Marketing, 2020
The article examines the relationship between subsidies paid and the profitability achieved on small agricultural holdings in Bulgaria. The regression analysis examines the relationship between subsidies as factorial values ​​and indicators – gross ...
Nikolaj Stefanov
doaj  

Horticultural systems based on greenhouse tomato in south Uruguay: characterization and analysis of economic efficiencies

Agrociencia, 2020
Sustainable development of food production requires more productive, profitable, and resource-efficient farming systems. Economic efficiency depends on commercial yield, but also on the efficient use of inputs, their price, and the sale price of products;
María Cecilia Berrueta, Santiago Dogliotti, Gustavo Giménez   +2 more
doaj   +1 more source

WUE and CO₂ Estimations by Eddy Covariance and Remote Sensing in Different Tropical Biomes

Remote Sensing, 2022
The analysis of gross primary production (GPP) is crucial to better understand CO2 exchanges between terrestrial ecosystems and the atmosphere, while the quantification of water-use efficiency (WUE) allows for the estimation of the compensation between ...
Gabriel B. Costa, Cláudio M. Santos e Silva, Keila R. Mendes, José G. M. dos Santos, Theomar T. A. T. Neves, Alex S. Silva, Thiago R. Rodrigues, Jonh B. Silva, Higo J. Dalmagro, Pedro R. Mutti, Hildo G. G. C. Nunes, Lucas V. Peres, Raoni A. S. Santana, Losany B. Viana, Gabriele V. Almeida, Bergson G. Bezerra, Thiago V. Marques, Rosaria R. Ferreira, Cristiano P. Oliveira, Weber A. Gonçalves, Suany Campos, Maria U. G. Andrade   +21 more
doaj   +1 more source

Improved Gross Efficiency during Long Duration Submaximal Cycling Following a Short-term High Carbohydrate Diet

International Journal of Sports Medicine, 2013
To assess the effect of dietary manipulation on gross efficiency (GE), 15 trained male cyclists completed 3×2 h tests at submaximal exercise intensity (60% Maximal Minute Power).
M. Cole, D. Coleman, J. Hopker, J. Wiles
semanticscholar   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source