Results 21 to 30 of about 112,457 (217)
Frontiers in Physiology, 2018 Longer distance cross-country ski (14–220 km) races such as the Visma Ski Classics (VSC) has recently gained attention in addition to the traditional Olympic distances (5–50 km) associated with cross-country (XC) skiing.
Edvard H. Sagelv +8 more
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Известия Томского политехнического университета: Инжиниринг георесурсов, 2009 The profile of the advanced triple cycle steam-gas plant has been selected. The authors have developed the mathematical model for calculating the indicators of triple cycle steam-gas plant.
N. N. Galashov, S. A. Tsibulsky
doaj +2 more sources
Output volatility and efficiency gains: evidence from Latin American gross value added
Journal of Applied Economics, 2021 Based on gross value added (GVA) shares of economic activities from 1990 to 2014, the paper shows that convex growth-instability frontiers exist for 19 Latin American countries. Numerical simulations show that in 2011, Latin America's industry portfolios
Kurt A. Hafner
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Entropy, 2019 The performance of a 300 kW organic Rankine cycle (ORC) prototype was experimentally investigated for low-grade waste heat recovery in industry. The prototype employed a specially developed single-stage radial turbine that was integrated with a semi ...
Ruijie Wang +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Determining the Efficiency and Inefficiency Intervals of Crop Production in Iran [PDF]
پژوهشهای اقتصادی, 2020 In this study, using the classic and developed models of data envelopment analysis, the frontiers of efficiency and inefficiency were determined for 29 irrigated crops and the relative position of products was determined in terms of gross income and ...
ali shahnavazi
doaj
Identification of a general light use efficiency model for gross primary production [PDF]
Biogeosciences, 2011 Non-stationary and non-linear dynamic time series analysis tools are applied to multi-annual eddy covariance and micrometeorological data from 44 FLUXNET sites to derive a light use efficiency model for gross primary production on a daily basis.
J. E. Horn, K. Schulz
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