AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
Assessment of water use efficiency in arid ecosystems of the coastal land of Egypt using MODIS dataset. [PDF]
Sci RepHotaiba AM, Salem BB, Halmy MWA.
europepmc +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Six weeks of high-intensity interval training improve autonomic and metabolic responses in active postmenopausal women. [PDF]
Exp PhysiolMonferrer-Marín J +3 more
europepmc +1 more source
Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury
Advanced Science, EarlyView.Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang +14 more
wiley +1 more source
Regulatory Design and Long-Term Growth: Insights from China's Experience for Latin America. [PDF]
F1000ResValdiglesias J.
europepmc +1 more source
Oral History Interview with Gross, Bowser and Johnson
The National Museum of the Pacific War presents an interview with Bowser, Gross and Johnson. The three-way conversation begins with Frank Gross discussing his activity at the Battle of Wake Island when the garrison had to surrender to the Japanese at the
Gross, Johnson, Gross, Bowser
core
Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming
Advanced Science, EarlyView.Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du +15 more
wiley +1 more source
Machine Model-Specific Delivery Sequence Optimization for Spot-scanning Proton Arc Therapy Using a Compact Superconducting Synchrocyclotron. [PDF]
Med PhysLiu P +5 more
europepmc +1 more source
Advanced Science, EarlyView.A Li+‐DES system enables targeted defluorination and synergistic repair of spent LiCoO2 cathodes in a single medium. The regenerated material recovers a well‐ordered layered structure with a high capacity of 157.4 mAh g−1 and 83.1% capacity retention after 300 cycles, demonstrating a sustainable and efficient closed‐loop recycling strategy for lithium ...
Yingjie Hu +9 more
wiley +1 more source