Results 171 to 180 of about 133,188 (300)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Socioeconomic determinants of leprosy in Brazilian municipalities: an ecological study. [PDF]

An Bras Dermatol
Golineli AOG, Belli MCV, Lourenço GH, Belli O, Miot HA.   +4 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Incremental Reform and Distortions in China’s Product and Factor Markets

The purpose of economic reform is to reduce distortions and enhance efficiency. However, when reforms are partial and incremental, individuals and local governments are often able to capture the rent inherent in the gradual transition process.
Tan, Kong-Yam, Zhang, Xiaobo
core  

Measuring Gross National Refugee Product: A Framework for the Classification of Refugee Source Countries

Refuge, 1982
Firdaus Kharas
doaj   +1 more source

Radical Deoxygenation of Alcohols via Visible Light Irradiation of a Titanium Porphyrin Catalyst. [PDF]

Org Lett
Gross BM, Razavi S, de Almenara AJ, Stoltz BM.   +3 more
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Impact of the compact county medical service community policy on healthcare resource allocation and healthcare service utilization in village clinics: a difference-in-differences analysis in rural Sichuan, China. [PDF]

Front Public Health
Li M, Fu L, Mo A, Li L, Lin Y.
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

ANALISIS DETERMINASI PERDAGANGAN INTERNASIONAL TERHADAP PERTUMBUHAN GNP (GROSS NATIONAL PRODUCT) PADA EMPAT NEGARA EMERGING MARKET DI KAWASAN ASEAN DI TINJAU EKONOMI ISLAM (2018-2022)

ABSTRAK Pertumbuhan ekonomi dapat dilihat melalui dua indikator yaitu dapat dilihat dari GDP (Gross Domestic Product) dan GNP (Gross National Product).
NOVA, FIONITA
core