Results 121 to 130 of about 142,240 (292)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Sensitivity Analysis of Biome-BGC for Gross Primary Production of a Rubber Plantation Ecosystem: A Case Study of Hainan Island, China. [PDF]

Int J Environ Res Public Health, 2022
Liu J, Wu Z, Yang S, Yang C.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Estimating mangrove forest gross primary production by quantifying environmental stressors in the coastal area. [PDF]

Sci Rep, 2022
Zheng Y, Takeuchi W.
europepmc   +1 more source

Estimates of vertical turbulent mixing used to determine a vertical gradient in net and gross oxygen production in the oligotrophic South Pacific Gyre

Geophysical Research Letters, 2016
Mixed layer (ML) gross (GOP) and net (NOP) oxygen production rates based on in situ mass balances of triple oxygen isotopes (TOI) and O2/Ar are influenced by vertical transport from below, a term traditionally difficult to constrain.
W. Z. Haskell II, M. G. Prokopenko, R. H. R. Stanley, A. N. Knapp   +3 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Appendix A. Daily estimates of gross primary production and ecosystem respiration in the upper and lower reaches of French Creek.

, 2016
Daily estimates of gross primary production and ecosystem respiration in the upper and lower reaches of French ...
Erin R. Hotchkiss (2928705), Robert O. Hall Jr. (2904179)   +1 more
core   +1 more source

A global 0.05° dataset for gross primary production of sunlit and shaded vegetation canopies from 1992 to 2020. [PDF]

Sci Data, 2022
Bi W, He W, Zhou Y, Ju W, Liu Y, Liu Y, Zhang X, Wei X, Cheng N.   +8 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

METHODOLOGY FOR STUDIES OF CARBON DYNAMICS BETWEEN PHYTOPLANKTON PRIMARY PRODUCTION AND HETEROTROPHIC BACTERIAL SECONDARY PRODUCTION

, 1989
The SCENTO-System was used to study the carbon dynamics between phytoplankton primary production and heterotrophic bacterial secondary production. Most of the methods used nowadays in situ for limnological synecology studies were applied.
INST HYDROBIOL, ACAD SINICA, WUHAN, CHINA, LIN W, OVERBECK J   +2 more
core