Results 71 to 80 of about 1,049,045 (249)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Determination of shaliness parameters of terrigenous rocks in cased boreholes and while drilling by radioactive logging combination

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Геологія. Географія. Екологія
Introduction. Shaliness is an important lithological and petrophysical characteristic of reservoirs and seals in section of oil-and-gas boreholes as well as near-surface rocks (grounds) as the basis of buildings and engineering structures.
Максим Бондаренко, Володимир Кулик   +1 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Drip irrigation apple tree in Azerbaijan with using biohumus with mineral fertilizers

Юг России: экология, развитие, 2015
The main purpose of the study is an introduction to new technology micro irrigation of the rational using micro irrigation with use biohumus and mineral fertilizers (NPK) in appl  garden in condition of the Guba region of the Azerbaijani Republic.
I. B. Salmanov
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Modeling of building structures when transferring dynamic effects through the soil mass

Nauka ta progres transportu, 2011
Factors influenced on strength parameters of constructions of exploiting buildings in difficult engineergeological conditions are analysed. Influence of dynamic forces, including forces from a public transport on the exploiting building is shown.
V.A. Banakh
doaj  

From Composite Building to Partial Figure: Variations in the Teaching of Colin Rowe and Peter Eisenman

Les Cahiers de la Recherche Architecturale, Urbaine et Paysagère, 2019
This paper undertakes a comparative analysis of Colin Rowe (1920-1999) and Peter Eisenman’s (1932-) studio teaching as a form of theoretical practice.
Michael Jasper
doaj   +1 more source

Ground confluence [PDF]

, 1987
In this paper we introduce a test for confluence on ground terms. This test allows us to prove the ground confluence of term rewriting systems where the Knuth-Bendix Algorithm does not terminate. Ground Confluence of term rewriting systems is sufficient, if one is interested in congruences on ground terms.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source