Results 121 to 130 of about 2,760,154 (306)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Designed Interaction Potentials via Inverse Methods for Self-Assembly
, 2006 We formulate statistical-mechanical inverse methods in order to determine optimized interparticle interactions that spontaneously produce target many-particle configurations.
Frank Stillinger +5 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Laboratory Simulation of the Effect of Rocket Thrust on a Precessing Space Vehicle [PDF]
Ground tests of solid propellant rocket motors have shown that metal-containing propellants produce various amounts of slag (primarily aluminum oxide) which is trapped in the motor case, causing a loss of specific impulse.
Alvarez, Oscar +7 more
core +1 more source
Controlling a Van Hove singularity and Fermi surface topology at a complex oxide heterostructure interface. [PDF]
, 2019 The emergence of saddle-point Van Hove singularities (VHSs) in the density of states, accompanied by a change in Fermi surface topology, Lifshitz transition, constitutes an ideal ground for the emergence of different electronic phenomena, such as ...
Ahadi, Kaveh +5 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
DronesUnmanned aerial vehicles (UAVs) are now widely preferred systems that are capable of rapid mapping and generating topographic models with relatively high positional accuracy.
Hasan Bilgehan Makineci +2 more
doaj +1 more source
Generation of Virtual Ground Control Points Using a Binocular Camera
DronesThis paper presents a methodology for generating virtual ground control points (VGCPs) using a binocular camera mounted on a drone. We compare the measurements of the binocular and monocular cameras between the classical method and the proposed one. This work aims to decrease human processing times while maintaining a reduced root mean square error ...
Ariel Vazquez-Dominguez +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source