Results 111 to 120 of about 1,592 (218)

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2607-2623, August 2026.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2672-2681, August 2026.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, Volume 11, Issue 4, Page 1214-1226, August 2026.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Tracing river dynamics: Multi‐temporal planform evolution and morphological change analyses in a meandering reach using high‐resolution satellite imagery and UAV data

Earth Surface Processes and Landforms, Volume 51, Issue 8, August 2026.
High‐resolution satellite imagery and UAV data enabled detailed morphometric parameter calculation, meander classification and multi‐epoch change detection for the Atrak River's meandering channel. Our results reveal rapid, episodic migration and a nearly tenfold surge in bank erosion triggered by the 2019 extreme flood, with persistent instability at ...
Aiding Kornejady, Mohammadreza Gharibreza, Christian Conoscenti, Behrooz Mohseni, Saeid Shabani   +4 more
wiley   +1 more source

Farming in the shadows of Rome: A multi‐proxy palaeoenvironmental record from Loch Clunie—Perthshire

Journal of Quaternary Science, Volume 41, Issue 6, Page 915-932, August 2026.
ABSTRACT Roman impacts on local society is a subject of international significance. Loch Clunie, Perthshire, lies only 5.4 km from Inchtuthil, the only Roman legionary fortress in Scotland, and contains two crannogs and a probable lakeside hillfort. Despite this proximity and the likelihood of local–Roman interaction, these sites remain unexcavated ...
Samantha E. Jones, Maarten Blaauw, Fraser Hunter, Olalla López‐Costas, Antonio Martínez Cortizas, Tim M. Mighall, Gordon Noble   +6 more
wiley   +1 more source

Nonlinear Kinematic Depth Inversion Coupled With a Spectral Wave Model

Journal of Geophysical Research: Oceans, Volume 131, Issue 8, August 2026.
Abstract We present a bidirectional coupling between a nonlinear kinematic depth inversion method and a phase‐averaged spectral wave model to evaluate the influence of wave nonlinearity over gently sloping nearshore bathymetry. Time‐resolved wave imagery provides spatially varying frequency–wavenumber fields, whereas the simulated significant wave ...
Byunguk Kim, Yong Sung Park, Hyoseob Noh, Seungjun Baek, Juyeong Hur   +4 more
wiley   +1 more source

GCP Placement Methods for Improving the Accuracy of Shoreline Extraction in Coastal Video Monitoring

한국해양공학회지
In coastal video monitoring, the direct linear transform (DLT) method with ground control points (GCPs) is commonly used for geo-rectification. However, current practices often overlook the impact of GCP quantity, arrangement, and the geographical ...
Changyul Lee, Kideok Do, Inho Kim, Sungyeol Chang   +3 more
doaj   +1 more source

Spatial Variability and Drivers of Salt Marsh Cliff Erosion in the Dutch Wadden Sea: From Observation to Simulation

Journal of Geophysical Research: Earth Surface, Volume 131, Issue 8, August 2026.
Abstract Lateral erosion of salt marshes via cliff retreat is a primary cause of global marsh loss, driven by interactions between hydrodynamics, sediment, and vegetation. While previous studies show a linear relationship between wave power and cliff retreat, models based on this relationship are largely unvalidated for short‐term (sub‐yearly) and ...
S. Dzimballa, V. Kitsikoudis, P. W. J. M. Willemsen, E. O. Folmer, B. W. Borsje, I. Y. Georgiou, M. C. Bregman, D. C. M. Augustijn   +7 more
wiley   +1 more source

Backrest Position and Outcome in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multi‐Center Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Intensive care following resuscitation from out‐of‐hospital cardiac arrest (OHCA) is based on a set of interventions, all of which are intended to reduce anoxic brain injury and improve outcomes, including sedation, mechanical ventilation, circulatory optimization, and temperature control protocols.
Jesper Kjaergaard, Jo Bønding Andreasen, Simon Mølstrøm, Bodil Steen Rasmussen, Steffen Christensen, Henrik Schmidt, Jacob Eifer Moeller, Lars Peter Kloster Andersen, Sören Möller, Christian Hassager, Martin A. S. Meyer, Simon Schneekloth, Laust Obling, Anders Morten Grejs   +13 more
wiley   +1 more source