Results 111 to 120 of about 1,590 (229)

The Danish Out‐of‐Hospital Cardiac Arrest Trial: A Statistical Analysis Plan

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Post‐cardiac arrest care for patients resuscitated from out‐of‐hospital cardiac arrest (OHCA) includes multiple pharmacological and physiological interventions, yet optimal strategies to reduce post‐cardiac arrest syndrome–related morbidity and mortality remain uncertain.
Simon Mølstrøm, Jacob E. Møller, Henrik Schmidt, Anders M. Grejs, Steffen Christensen, Jesper Kjærgaard, Christian Hassager, Martin A. S. Meyer, Lars P. K. Andersen, Bodil S. Rasmussen, Jo B. Andreasen, Sören Möller   +11 more
wiley   +1 more source

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Delirium is a frequent complication in comatose Out‐of‐Hospital Cardiac Arrest (OHCA) survivors requiring postresuscitation intensive care and is associated with higher mortality and longer hospitalization. Despite this, there is no established pharmacologic strategy for delirium prevention in OHCA survivors.
Benedikte Liebetrau, Anders M. Grejs, Martin A. S. Meyer, Lars P. K. Andersen, Sören Möller, Simon Mølstrøm, Jacob E. Møller, Henrik Schmidt, Steffen Christensen, Jesper Kjærgaard, Christian Hassager, Bodil S. Rasmussen, Jo B. Andreasen   +12 more
wiley   +1 more source

Dynamics of Body Composition and Metabolic Risk in Adolescents With Obesity Under GLP‐1 Receptor Agonist Therapy

Acta Paediatrica, Volume 115, Issue 8, Page 1726-1736, August 2026.
ABSTRACT Aim To explore changes in body composition in adolescents with obesity treated with glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) and their association with metabolic syndrome (MetS) components. Methods This real‐world retrospective study included adolescents (12–18 years) with obesity who received multidisciplinary lifestyle‐based ...
Adar Lopez, Liat Perl, Eyal Cohen‐Sela, Ophir Borger, Yael Issan, Hagar Interator, Erez Azoulay, Hadar Moran‐Lev, Ronit Lubetzky, Shira Zelber‐Sagi, Yael Lebenthal, Avivit Brener   +11 more
wiley   +1 more source

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Olamkicept up to 2400 mg in Healthy Men: Phase I, Randomized, Placebo‐Controlled, and Double‐Blind Trial

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Olamkicept is a first‐in‐class fully human fusion protein that selectively inhibits trans interleukin (IL)‐6 signaling. Previous phase I clinical trials demonstrated that single doses up to 750 mg and multiple doses up to 600 mg were safe and well tolerated in healthy men and women.
Stanislav Ignatenko, Alla Radicke, Katharina Bruzelius, Michael Falkenberg, Lars‐Erik Kyhl, Signe Møgelmose, Arjun Ravi, Philippe Pinton   +7 more
wiley   +1 more source

Clusterization‐Triggered Emission from Cellulose‐Based Luminophores in Dilute Aqueous Solution through Imine Formation

Advanced Functional Materials, Volume 36, Issue 58, 20 July 2026.
Clusterization‐triggered emission is realized in dilute aqueous solution by introducing imine linkages into cellulose‐based luminophores. Imine functionalization creates O/N‐rich, hydrogen‐bonded clustered microenvironments that stabilize emissive states and restrict molecular motions. Luminescence is tunable by amine type and multiplicity.
Yazhou Su, Akihide Sugawara, Madhurangika Panchabashini Horathal Pedige, Youhei Takeda, Satoshi Minakata, Hiroshi Uyama   +5 more
wiley   +1 more source

GCP Placement Methods for Improving the Accuracy of Shoreline Extraction in Coastal Video Monitoring

한국해양공학회지
In coastal video monitoring, the direct linear transform (DLT) method with ground control points (GCPs) is commonly used for geo-rectification. However, current practices often overlook the impact of GCP quantity, arrangement, and the geographical ...
Changyul Lee, Kideok Do, Inho Kim, Sungyeol Chang   +3 more
doaj   +1 more source

Bioequivalence of Two Firsekibart Subcutaneous Formulations: A Randomized, Double‐Blind, Single‐Dose, Parallel‐Group Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.
Abstract We evaluated the pharmacokinetic (PK) bioequivalence and safety of a new formulation of firsekibart (solution for injection) compared with firsekibart lyophilized powder for solution. In this randomized, double‐blind, parallel‐group study, healthy Chinese adult males received a single subcutaneous dose of 200 mg firsekibart solution for ...
Yehua Xie, Xiao Li, Yushi Chen, Guangli Ma, Fei Gu, Yuling Lian, Xu Zhang, Xiaolan Yong   +7 more
wiley   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, Volume 18, Issue 7, Page 922-932, July 2026.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

A Community‐Led Approach to Enhancing Informed Consent for Individuals With Vision Impairment

Diversity &Inclusion Research, Volume 3, Issue 3, July 2026.
ABSTRACT Participant Information and Consent Forms (PICFs) are critical documents that help promote informed decision‐making about research participation. However, many PICFs remain inaccessible to people with diverse needs, including those experiencing print disability.
Fleur O'Hare, David Foran, Tessa Saunders, Lisa Eckstein, Gudrun Wells, Daniel Talko, Kevin Lee, Shane Somerville, Debra Simons, Grace King, Michael Burmeister, John Paul Cruz, Camille Paynter, Lauren N. Ayton   +13 more
wiley   +1 more source

Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background and Objective Fibromyalgia (FM) is a nociplastic chronic pain syndrome in which neuroimaging indicates central nervous system involvement, yet findings remain inconsistent across methods. We systematically reviewed structural and functional neuroimaging studies in adults with FM to identify the most reproducible cross‐modal ...
Flávio Antônio Duboc Flutt, João Pedro de Melo Cortez, Lucas Rego Ramos, Rayssa Paula Paz Furlanetto, Diogo Goulart Corrêa, Nivaldo Ribeiro Villela   +5 more
wiley   +1 more source