Results 241 to 250 of about 962,375 (304)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Typhoon short-term heavy precipitation warning based on dual-polarization radar observations of precipitation particle vertical distribution. [PDF]

Sci Rep
Fang R, Wang T, Liu H.
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

A hybrid RSM-PSO-ANN approach for developing cleaner-label emulsified sausages with roasted <i>Lyophyllum decastes</i> mushroom powder: Optimization, quality, and antioxidant activity. [PDF]

Food Chem X
Chen W, Yang H, Li X, Li W, Wu D, Zhang Z, Liu P, Pang X, Yang Y, Wang X.   +9 more
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Recent extremes in Antarctic sea ice extent modulated by ocean heat ventilation. [PDF]

Proc Natl Acad Sci U S A
Wilson EA, Arlen L, Campbell EC.
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Estimation of liquefaction-induced settlement of shallow foundation by machine learning with imbalanced data. [PDF]

Sci Rep
Sargin S, Korkmaz G, Yildirim AK, Yalcin Kavus B, Karaca TK.   +4 more
europepmc   +1 more source

What are the differences between on-ice and off-ice side-cutting maneuver? A kinematic and electromyographic comparative analysis of ice hockey players. [PDF]

Front Bioeng Biotechnol
Yu Z, Bi G, Wang W, Qin Y, Song Z, Wu F.
europepmc   +1 more source

Critical Limitations in Cryogenic Laser Cooling of Solids: Symmetry-Related Fluorescence Trapping and Condensation-Induced Parasitic Heating. [PDF]

Adv Sci (Weinh)
Zhong B, Zhang J, Yang H, Deng L, Tonelli M, Luo E.   +5 more
europepmc   +1 more source