Results 61 to 70 of about 6,019,923 (289)

Near-Collapse Probability of RC Frames in Indonesia Under Repeated Earthquakes Containing Fling-Step Effect

International Journal of Technology, 2023
The velocity pulse and displacement fling-step pulse signatures may be present in a near-field earthquake ground motion record. It is generally known that near-field ground motion with pulse effects accelerated the building drift.
Ade Faisal, Afiful Anshari, Fadzli Mohamed Nazri, Moustafa Moufid Kassem   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Reliability-based ductility reduction factors surfaces using the generalized bojorquez ground motion intensity measure IBg

Results in Engineering
In this work, reliability-based ductility reduction factors surfaces are obtained through uniform annual failure rate (UAFR) spectra. For this aim, several nonlinear single degree of freedom (SDOF) systems that include various hysteretic behavior models,
Edén Bojórquez, Joel Carvajal, Sonia E. Ruiz, Juan Bojórquez   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Dependence of RC high-rise buildings response on the earthquake intensity

Građevinar, 2015
The relationship between the ground motion intensity measure, IM, and the engineering demand parameter, EDP, is analysed in the paper so as to identify and define the most efficient EDP-IM relationships for RC high-rise buildings. A 30-story RC high-rise
Jelena Pejović, Srđan Janković
doaj   +1 more source

Scenario-based earthquake damage assessment of highway bridge networks

Advances in Bridge Engineering, 2023
In earthquake-prone regions, the evaluation of seismic impacts on bridges is crucial to mitigation, emergency, and recovery planning for highway networks. The degree of bridge damage determines the cost and time required for repairs and the level of post-
Ahmad Abo-El-Ezz, Azarm Farzam, Hamza Fezai, Marie-José Nollet   +3 more
doaj   +1 more source

Dynamic Damage Mechanism and Seismic Fragility Analysis of an Aqueduct Structure

Applied Sciences, 2021
The Concrete Damaged Plasticity (CDP) constitutive is introduced to study the dynamic failure mechanism and the law of damage development to the aqueduct structure during the seismic duration using a large-scale aqueduct structure from the South-to-North
Xinyong Xu, Xuhui Liu, Li Jiang, Mohd Yawar Ali Khan   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Seismic Fragility Analysis of RC Frames Under Near-Field and Far-field Ground Motion Based on Spectral Matching

工程科学与技术, 2018
Choosing the appropriate ground motion as input is the basis of nonlinear dynamic analysis and incremental dynamic analysis of structures.Firstly,20 suites of near-field ground motion records and 20 suites of far-field ground motion records were chosen ...
Jianping HAN, Shilong WEI, Xin ZHANG
doaj