Results 51 to 60 of about 640,600 (307)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exclusive Electro-Disintegration of 3He at high Q2: II. Decay Function Formalism

, 2005
Based on the theoretical framework of generalized eikonal approximation we study the two-nucleon emission reactions in high $Q^2$ electro-disintegration of $^3He$.
L. L. Frankfurt, M. I. Strikman, M. M. Sargsian, T. V. Abrahamyan, Y. I. Azimov   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Assessment of ground reaction force during scoliotic gait [PDF]

European Spine Journal, 2004
Although the causes and progression of adolescent idiopathic scoliosis (AIS) are still unclear, a recent extensive review has indicated a number of possible aetiological factors. Previous investigations, employing gait measurements, have indicated asymmetries in the ground reaction forces and suggest a relationship between these asymmetries ...
Nachiappan, Chockalingam, Peter H, Dangerfield, Aziz, Rahmatalla, El-Nasri, Ahmed, Tom, Cochrane   +4 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Comparsion of the Electromyography of Leg Muscles and Peak Vertical Ground Reaction Forces during Single Leg Drop Landing between Men with Genu Varum Deformity and Normal Knee [PDF]

Sport Sciences and Health Research, 2013
The aim of this study was to compare the electromyography of leg muscles and the peak vertical ground reaction forces during single leg drop landing of men with genu varum deformity and normal knee.
Mohammadreza Mahaki, seyedsadredin shojaedin, Raghad Memar, Mehdi Khaleghi Nazji   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Gait ground reaction force characteristics in children with and without forward head posture [PDF]

Journal of Kerman University of Medical Sciences, 2019
Background: Forward head posture is one of the most prevalent abnormal postures in patients with neck disorders. The aim of this study was to evaluate the effects of forward head posture on gait ground reaction force characteristics in children. Methods:
AmirAli Jafarnezhadgero, Hamed Sheikhalizade   +1 more
doaj   +1 more source

Ground reaction forces during level ground walking with body weight unloading [PDF]

Brazilian Journal of Physical Therapy, 2014
Partial body weight support (BWS) systems have been broadly used with treadmills as a strategy for gait training of individuals with gait impairments. Considering that we usually walk on level ground and that BWS is achieved by altering the load on the plantar surface of the foot, it would be important to investigate some ground reaction force (GRF ...
Barela, Ana M. F., Freitas, Paulo B. de, Celestino, Melissa L., Camargo, Marcela R., Barela, José A.   +4 more
openaire   +6 more sources