Results 31 to 40 of about 11,564 (258)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Experimental performance analysis of a multiple-source and multiple-use heat pump system: winter field experiment and heating operation performance evaluation [PDF]

E3S Web of Conferences, 2019
We herein report the development of a distributed heat pump system that can utilize a variety of renewable energy sources to meet different building heating and cooling demands (i.e., a multiple source and multiple use heat pump system, MMHP).
Liu Mingzhe, Ooka Ryozo, Hino Toshiyuki, Wen Ke, Choi Wonjun, Lee Doyun, Ikeda Shintaro, Reza Palasz Djafar   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparative Analysis of Resource and Climate Footprints for Different Heating Systems in Building Information Modeling

Buildings, 2022
Buildings play an important role to meet Sustainable Development Goals, especially regarding the use of resources and greenhouse gas emissions. They are increasingly designed with energy-efficient solutions regarding their operations, while the related ...
Husam Sameer, Guillaume Behem, Clemens Mostert, Stefan Bringezu   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Study on optimization and time effect of ground-source heat pump system in Nanjing

Shuiwen dizhi gongcheng dizhi
The reasonable design of hole spacing for buried heat exchangers is the first issue to be solved when developing shallow geothermal energy in the Nanjing erosion and accumulation plain area.
Qi FAN, Linshan YUAN, Cunfa ZHAO, Rong TIAN   +3 more
doaj   +1 more source

Performance Prediction Model Based on Multi-Task Learning and Co-Evolutionary Strategy for Ground Source Heat Pump System

IEEE Access, 2019
In order to effectively predict the performance of ground source heat pump system, a performance prediction method is proposed in this paper. Based on the basic model of forward neural network, the algorithm predicts the performance data of ground source
Zhaoyi Zhuang, Chen Wei, Bing Li, Peng Xu, Yifei Guo, Jiachang Ren   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source