Results 151 to 160 of about 12,885 (290)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Failure Analysis of Girth Weld Cracking in Gas Transmission Pipelines Subjected to Ground Subsidence and Traffic Loads. [PDF]

Materials (Basel)
Li L, Yan X, Zhu L, Wu G, Zhang S.
europepmc   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Electrohydraulic Folding Ring Actuators for Radially Contracting Applications

Advanced Science, EarlyView.
This work presents an Electrohydraulic Folding Ring Actuator that combines high‐performance electrohydraulic actuation with origami‐inspired folding geometry to achieve constricting radial actuation. This integration yields significant inner lumen constriction, alongside a gripping force capable of holding objects exceeding four times the actuator's ...
Gavril Yong En Tan, Quan Xiong, Jonathan William Ambrose, Zeynep Altundal, Raye Chen‐Hua Yeow   +4 more
wiley   +1 more source

Kalman Filters in Geotechnical Monitoring of Ground Subsidence Using Data from MEMS Sensors. [PDF]

Sensors (Basel), 2016
Li C, Azzam R, Fernández-Steeger TM.
europepmc   +1 more source

Current Status and Future Prospects of Mining Subsidence and Ground Control Technology in China

, 2009
Mining of coal alters the ground stressfields, causing strata deformation, ultimately leading to surface subsidence. For the past 40 years some significant experience on mine subsidence control technology has been acquired in China, particularly when ...
Y Zou (7635278), Y Liu (4702669), W Guo (9858170)   +2 more
core  

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Extra Climate Benefits From Afforestation Due to Reduced Forest Fragmentation in China

Advanced Science, EarlyView.
Afforestation in China reduced forest fragmentation in 2015, transforming 51.8 M ha of edge forests into interior forests. This enhanced carbon sequestration (1.4±0.2 Pg CO2e, a cooling biogeochemical effect), while reduced albedo (−0.9 Pg CO2e, a warming biophysical effect) partially offset the gain, yielding a net extra climate benefit of ...
Nan Meng, Wei Li, Philippe Ciais, Martin Brandt, Xiaowei Tong, Yanzheng Yang, Guofeng Shen, Wei Du, Lei Zhu, Yi Leng, Minxuan Sun, Mengjie Han, Xuemei Zhang, Jie Zhang, Nan Wang, Dan Tong, Chao Wu, Wenhao Dong, Shu Tao, Bo Pan   +19 more
wiley   +1 more source