Results 41 to 50 of about 1,261,630 (267)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
“This ground truth is muddy anyway”
Sociologisk ForskningThis article explores assemblages of ground truth datasets for the development of medical artificial intelligence (AI). By drawing from interviews and observations, I examine how AI experts developing medical AI relate to the referential truth basis of ...
Charlotte Högberg
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Blockchain-Based Crowdsourcing Framework for Machine Learning Ground Truth
IEEE AccessMachine learning has evolved from a lab curiosity to a widely used technology that is fundamentally reliant on ground truth data for model training and evaluation.
Asma S. Alzahrani +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
TOWARDS GLOBALLY CONSISTENT SCAN MATCHINGWITH GROUND TRUTH INTEGRATION [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 The scan matching based simultaneous localization and mapping method with six dimensional poses is capable of creating a three dimensional point cloud map of the environment, as well as estimating the six dimensional path that the vehicle has travelled ...
J. Gailis, A. Nüchter
doaj +1 more source
A Framework for Evaluating Motion Segmentation Algorithms
, 2017 There have been many proposals for algorithms segmenting human whole-body motion in the literature. However, the wide range of use cases, datasets, and quality measures that were used for the evaluation render the comparison of algorithms challenging. In
Asfour, Tamim +4 more
core +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
FASSEG: A FAce semantic SEGmentation repository for face image analysis
Data in Brief, 2019 The FASSEG repository is composed by four subsets containing face images useful for training and testing automatic methods for the task of face segmentation.
Sergio Benini +4 more
doaj +1 more source