Results 41 to 50 of about 1,270,932 (284)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Reticulin‐Free Quantitation of Bone Marrow Fibrosis in MPNs: Utility and Applications

open access: yeseJHaem
Background Automated quantitation of marrow fibrosis promises to improve fibrosis assessment in myeloproliferative neoplasms (MPNs). However, analysis of reticulin‐stained images is complicated by technical challenges within laboratories and variability ...
Hosuk Ryou   +9 more
doaj   +1 more source

MiBio: A dataset for OCR post-processing evaluation

open access: yesData in Brief, 2018
We introduce a dataset for OCR post-processing model evaluation. This dataset contains fully aligned OCR texts and the ground truth recognition texts of a English biodiversity book.
Jie Mei   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Ground truth data requirements for altimeter performance verification [PDF]

open access: yes, 1972
The amount and type of ground truth required for an altimeter experiment is a function of the uncertainty in the satellite orbit, the altimeter error budget and the type of operation being performed.
Walsh, E. J.
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

“This ground truth is muddy anyway”

open access: yesSociologisk Forskning
This article explores assemblages of ground truth datasets for the development of medical artificial intelligence (AI). By drawing from interviews and observations, I examine how AI experts developing medical AI relate to the referential truth basis of ...
Charlotte Högberg
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Blockchain-Based Crowdsourcing Framework for Machine Learning Ground Truth

open access: yesIEEE Access
Machine learning has evolved from a lab curiosity to a widely used technology that is fundamentally reliant on ground truth data for model training and evaluation.
Asma S. Alzahrani   +3 more
doaj   +1 more source

TOWARDS GLOBALLY CONSISTENT SCAN MATCHINGWITH GROUND TRUTH INTEGRATION [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
The scan matching based simultaneous localization and mapping method with six dimensional poses is capable of creating a three dimensional point cloud map of the environment, as well as estimating the six dimensional path that the vehicle has travelled ...
J. Gailis, A. Nüchter
doaj   +1 more source

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