Results 81 to 90 of about 9,646,686 (304)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Design Methods of Underwater Grounding Electrode Array by Considering Inter-Electrode Interference for Floating PVs

open access: yesEnergies, 2018
An optimal design method is proposed in this paper to improve the safety and price competitiveness of floating photovoltaic (PV) systems. From the standards for grounding by the International Electrotechnical Commission (IEC) 60364, the Electrical ...
Byeong Gwan Bhang   +6 more
doaj   +1 more source

Investigation of transformer banks withdelta-connected secondary windings andvarious grounding methods for delta service

open access: yes, 2016
Grounding at source transformers or generators in a distribution system can help to stabilise system voltages and enhance overall reliability and safety.
Liao Rih-Neng, Chen Tsai Hsiang
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ethical Foreground and Background in Adult Educator Work

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Exploring Untrained Zero-Shot Visual Grounding: Proposal Generation and Unsupervised Alignment Techniques

open access: yes, 2023
reservedThis thesis approaches the task of visual grounding, which refers to the process of aligning words or phrases in natural language to specific objects or regions within an image.
BUTTAU, SARA
core  

agstub/grounding-line-methods: First release of full-Stokes grounding line dynamics solver

open access: yes, 2020
FEniCS code developed for a manuscript describing a numerical method for full-Stokes grounding line dynamics in the subglacial lake and ice-ocean settings: A.G. Stubblefield, M. Spiegelman, and T.T.
Aaron Stubblefield
core   +1 more source

Understanding of Grounding Systems' Performance with Equivalent Circuit Model

open access: yes, 2021
It has been known that under high impulse conditions, a non-linearity in some practical grounding electrodes, subjected to fast surges was observed. Inductive component can also be significant in grounding electrodes subjected to high impulse conditions,
Syed Abdullah, Syarifah Amanina   +7 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio   +8 more
wiley   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

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