Results 191 to 200 of about 5,446,403 (344)

Zooming Towards Better Health: Participant Experience in a Web-Based Group Cognitive Behavioral Intervention [PDF]

, 2018
Jannat Saini, Ashley Owen, Anna Hammer, William Brown, Ambar Kulshreshtha   +4 more
openalex   +1 more source

The challenge of sustainability: Long-term results from the Fifty-Fifty peer group-based intervention in cardiovascular risk factors

, 2021
Juan Miguel Fernández-Alvira, Rodrigo Fernández‐Jiménez, Mercedes de Miguel, Gloria Santos-Beneit, Patricia Bodega, Christopher A. Hill, Vanesa Carral, Carla Rodríguez, Isabel Carvajal, Xavier Orrit, Amaya de Cos-Gandoy, Marian Dal Re, Teresa Robledo, Valentı́n Fuster   +13 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Artificial intelligence based prediction model of in-hospital mortality among females with acute coronary syndrome: for the Jerusalem Platelets Thrombosis and Intervention in Cardiology (JUPITER-12) Study Group [PDF]

Ranel Loutati, Nimrod Perel, David Marmor, Tommer Maller, Louay Taha, Itshak Amsalem, Rafael Hitter, Manassra Mohammed, Nir Levi, Maayan Shrem, Motaz Amro, Mony Shuvy, Michael Glikson, Elad Asher   +13 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ENFORCER, internet-based interventions for cardiac arrest survivors: A study protocol for a randomised, parallel-group, multicentre clinical trial

Lorenzo Gamberini, Paola Rucci, Camilla Dolcini, Martina Masi, Laura Simoncini, Marco Tartaglione, Donatella Del Giudice, Rosa Domina, Andrea Fagiolini, Pamela Salucci, Giovanni Giuliani, Chiara Capozzi, Gianluca Zani, Concetta Lanza, Savino Spadaro, Milo Vason, Maila Mancini, Tommaso Tonetti, Gabriele Melegari, Carlo Pegani, Michele Zuliani, Alice Pravisani, Davide Colombo, Giammaria Cammarota, Rosanna Vaschetto, Giuseppe Ristagno, Nicola Pedroni, Emanuele Rezoagli, Giuseppe Marchese, Fabio Sangalli, Cristina Panzeri, Francesca Verginella, Alberto Cucino, Giulia Roveri, Vittorio Pavoni, Giuliano Michelagnoli, Jacopo Cappellini, Federica Stella, Sonia D’Arrigo, Filippo Sanfilippo, Paolo Murabito, Mariachiara Ippolito, Luca Carenzo, Annalisa Piccolo, Carlo Coniglio, Elisa Bresadola, Emanuele Russo, Marianna Madia, Cristina Santonocito, Jessica Giuseppina Maugeri, Carola Matellon, Matteo Filippini, Riccardo Tucci, Daniele Celin, Guglielmo Imbriaco   +54 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Group-Based Integrative Pain Management in Primary Care: A Study Protocol for Multilevel Interventions to Address Health Disparities

Maria T. Chao, Ariana Thompson‐Lastad, Pamela Swedlow, Sudha Prathikanti, Wendy Hartogensis, Folashade Wolfe-Modupe, Jesse Wennik   +6 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source