Results 131 to 140 of about 27,019,645 (348)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Identification of N,N‐Dimethylproline as the N‐Terminal Blocking Group of Crithidia oncopelti Cytochrome c557 [PDF]
, 1980 Gary M. Smith, Graham W. Pettigrew
openalex +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, EarlyView.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Feelings of Others Don't Impress Me Much – Effects of Living Group Climate on Empathy in Adolescent Male Offenders [PDF]
, 2016 E. J. E. Heynen +4 more
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Group representations without groups
Commentarii Mathematici Helvetici, 1979 Gabriel, P., Riedtmann, Ch.
openaire +2 more sources
Symplectic Groups as Galois Groups
Journal of Algebra, 2000 Let \(\mathbb{F}\) be a field containing the field of order \(q\), let \(x\) and \(t\) be indeterminates, let \(m\) be an integer greater than 1, and let \[ \widehat{f}(Y)= Y^{q^{2m}}+ t^q Y^{q^{m+1}}+ xY^{q^m}+ tY^{q^{m-1}}+Y. \] In [\textit{S. S. Abhyankar}, Proc. Am. Math. Soc. 124, 2977--2991 (1996; Zbl 0866.12005)], it was shown that, for \(m>2\),
openaire +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source