Results 171 to 180 of about 2,101,930 (408)

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

The prevalence of group A Streptococci carrier in healthy children in Gorgan

مجله دانشگاه علوم پزشکی گرگان, 2000
Streptococcal pharyngitis and rheumatic fever/rheumatic heart disease are among the major public health problems in children. In this study we assay the frequency of group A Beta hemolytic Streptococcus in nasopharynex of 1588 healthy 6-12 years children
E.Ghaemi (Ph.D), A.Tabarrai (M.Sc), M.R.Fazeli (M.D), M.A.Vakili (M.Sc), M.Bazoori (B.Sc)   +4 more
doaj  

Group A Streptococcus strains causing meningitis without distinct invasive phenotype

MicrobiologyOpen
Group A streptococcal (GAS; aka Streptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from ...
Laura Marquardt, Federica Andreoni, Mathilde Boumasmoud, Tiziano A. Schweizer, Dorothea M. Heuberger, Elena Parietti, Sanne Hertegonne, Jana Epprecht, Dario Mattle, Anna K. Raez, Ewerton Marques‐Maggio, Reto A. Schuepbach, Barbara Hasse, Srikanth Mairpady‐Shambat, Silvio D. Brugger, Annelies S. Zinkernagel   +15 more
doaj   +1 more source

Absorption of Group A Streptococcus Anti-M Typing Sera with Broken Cells [PDF]

, 1967
William K. Harrell, Helen Ashworth
openalex   +1 more source

Group A streptococcus cell-associated pathogenic proteins as revealed by growth in hyaluronic acid enriched media. [PDF]

, 2007
Ashbaugh, Berge, Burova, Caparon, Carapetis, Chaussee, Collin, Cunningham, Dixon, Dryla, Eng, Ferretti, Fiona M. McDonald, Frithz, Gary W. Black, Gasteiger, Gomi, Graham, Graham, Green, Guyre, Houtman, Husmann, Hynes, Hynes, Hynes, Ian Humphery-Smith, Johansson, Kansal, La Penta, Laurent, Lei, Levin, LiCalsi, Lukomski, Malke, Meng Zhang, Mims, Musser, Na, Nannini, Okada, Pancholi, Pancholi, Pancholi, Podbielski, Raeder, Raeder, Ratnayake-Lecamwasam, Senadheera, Shane S. Sturrock, Simon J. Charnock, Sjobring, Smith, Teng, Terao, Thongboonkerd, Voyich, Wilkins, Wilkins   +59 more
core   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

O-ACETYL GROUPS IN THE CELL WALL OF STREPTOCOCCUS FAECALIS

, 1958
Adolph Abrams
openalex   +1 more source

Field Application of Fluorescent Antibody Technique for Identification of Group A Streptococcus [PDF]

, 1961
William J. Peeples, D. W. Spielman, Max D. Moody   +2 more
openalex   +1 more source

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

Clinical Microbiology Reviews, 2014
M. Walker, T. C. Barnett, J. Mcarthur, J. Cole, J. Cole, C. Gillen, A. Henningham, A. Henningham, K. S. Sriprakash, M. Sanderson-Smith, V. Nizet, V. Nizet   +11 more
semanticscholar   +1 more source

The Prevalence of Antibiotic and Toothpaste Sensitivity Found in Oral Streptococcal Isolates in Healthy Individuals in the Okada Community of Nigeria [PDF]

, 2017
Background: This study aimed to determine the prevalence, antibiotic, and toothpaste sensitivity of oral streptococcal isolates in healthy individuals in the Okada community of Nigeria.
Mitsan, O. (Olley), Okwu, M. U. (Maureen)   +1 more
core