Results 121 to 130 of about 22,194,048 (265)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Improving Group Contribution Methods by Distance Weighting Amélioration de la méthode de contribution du groupe en pondérant la distance du groupe

Oil & Gas Science and Technology, 2013
A novel approach for improving estimations of existing group contribution methods is developed. Instead of fixed contributions, weighted contributions are optimized for each property estimation using a database.
Zaitseva A., Alopaeus V.
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Thermodynamic excess properties of 3,5- and 2,6-dimethylpyridine with cyclohexane measurement and prediction

MATEC Web of Conferences, 2013
The vapour pressures of liquid (3,5; 2,6)-dimethylpyridine with cyclohexane mixtures were measured by a static method in the range of 283.15–353.15 K. The pure components vapour pressures data and those of the mixtures were correlated with the Antoine ...
Ben-makhlouf-Hakem H., Ait-kaci A., Jose J.   +2 more
doaj   +1 more source

Antea Group Archeologie 2018/8

, 2018
In november/december 2017 (Haven 8-West) en februari 2018 (Haven 8-Oost) is door Antea Group in opdracht van de gemeente Waalwijk een inventariserend veldonderzoek, met proefsleuven. Dit voor het plangebied Haven 8 te Waalwijk.
Koopmanschap, Dr. H.J.L.C. (Antea Group)
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Estimation of Critical Properties of Eucalyptol, Alpha-Terpineol, Limonene, and Caryophyllene in Eucalyptus Oil (Melaleuca leucadendra) Using the Group Contribution Method

Jurnal Rekayasa Kimia & Lingkungan
Critical property estimation of compounds in eucalyptus oil has been conducted using the Group Contribution method to improve the accuracy of calculations of critical temperature (Tc), critical volume (Vc), critical pressure (Pc), and normal boiling ...
Muhammad Dewa Prasetyo, Srie Muljani, Amilia Putri Puspita Sari   +2 more
doaj   +1 more source

Level of 25(Oh)D Serum, Expression of Interleukin 4 and Glucocorticoid Receptor of Mononuclear Cell in Steroid Resistance Nephrotic Syndrome Children [PDF]

Journal of Tropical Life Science, 2015
Nephrotic syndrome (NS) is an autoimmune disease and its steroid resistance status supposed correlate with 25(OH)D level and IL-4 expression. The aimed of this study was investigated 25(OH)D plasma level, IL-4 and GR expression of PBMC in steroid ...
Vonny Mariany Deckert, Krisni Subandiyah, Loeki Enggar Fitri   +2 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source