Results 241 to 250 of about 18,259,694 (281)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Black Studies Discussion Group Newsletter, Issue 1

, 1898
Black Studies Discussion Group
core  

Lifetime prediction of polymers through short term TGA experiments: real chance or low reliability?

, 2013
BLANCO, Ignazio
core  

Grasshoppers Farmers discussion group, Grasshoppers

, 2019
Grasshoppers Farmers discussion group, Grasshoppers
core  

Group Discussion

, 2018
Group ...
David Campbell, Ros Draper, Clare Huffington   +2 more
openaire   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Summarization of discussion groups

Proceedings of the tenth international conference on Information and knowledge management - CIKM'01, 2001
In this paper, we describe an algorithm to generate textual summaries of discussion groups. Our system combines sentences extracted from individual postings into variable-length summaries by utilizing the hierarchical discourse context provided by discussion threads.
Robert G. Farrell, Peter G. Fairweather, Kathleen Snyder   +2 more
openaire   +2 more sources

The Discussion Group for Mortals

Journal of Clinical Oncology, 2006
“Late–middle-aged, bald, single-breasted woman seeking people interested in talking about death and dying.” This was the way Jaci wanted the advertisement to run for the discussion group she wanted me to put together at our Cancer Wellness Center (Northbrook, IL). We laughed.
openaire   +2 more sources