Results 131 to 140 of about 2,206 (230)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Noncyclic BCH and Srivastava codes over the subgroup of the groups of units of Galois rings [Formula: see text] for advanced error control. [PDF]

Sci Rep
Sajjad M, Bashir Q, Haleemzai I, Abdalrahem MK, Hazzazi MM.   +4 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Multi-view hybrid encoder U-Net for 3D renal vascular medical image segmentation. [PDF]

Sci Rep
Yan N, Tang L, Tao Y, Yao J, Guo Z, Liu M, Wang J.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Use of Deep Learning Models in the Diagnosis of Proptosis Through Orbital Magnetic Resonance Imaging. [PDF]

Med Sci Monit
Kesimal U, Akkaya HE, Polat Ö, Sağlam M.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Accelerating diagnosis of degenerative cervical myelopathy through improved education: a mixed-methods study protocol from Myelopathy.org RECODE-DCM to define stakeholders, knowledge requirements and an optimal intervention strategy. [PDF]

BMJ Open
Veremu M, Deakin N, Chauhan RV, Lantz JM, Toumbas G, Tabrah J, Kumar V, Zipser CM, Plener J, Ammendolia C, Anderson DB, Dos Santos Rubio EJ, Tetreault L, Parnaik R, Rodrigues-Pinto R, Ong'wen OM, Sarewitz E, Sadler I, Roberts T, Langridge N, Swait G, Hadfield-Law L, Draper-Rodi J, Wood L, Stacpoole S, Ganau M, Baig S, Bateman A, Demetriades AK, Peul WCW, Davies B.   +30 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

DEP-TFDualNet: A Dual-Domain Attention Framework with Temporal-Frequency Fusion for Depression Recognition Using Three-Channel Frontal EEG. [PDF]

Sensors (Basel)
Lin H, Liu J, Jiang D.
europepmc   +1 more source