Results 71 to 80 of about 36,439 (252)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Conditions for Singular Incidence Matrices [PDF]
Suppose one looks for a square integral matrixN, for which NN has a prescribed form.Then the Hasse-Minkowski invariants and the determinant of NN lead to necessary conditions for existence.The Bruck-Ryser-Chowla theorem gives a famous example of such ...
Haemers, W.H.
core +1 more source
, 2020 Bu tez Gruplara Bü lunebilen Tasarımlar (GDD'ler) uzerinedir. GDD'ler Kombina-oü ütoryel Tasarımlar Teorisindeki ana yapılardan birisidir. GDD'ler ilk defa 1975'deHanani tarafından tanımlanmıs ve o gunden bu yana mesala PBD, Frame ve BIBDş ügibi kombinatoryel yapıların insaasında sıkca kullanılmıstır.ş ş şBir GDD (X, G, B) uclusu ...
openaire +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Auctioning Many Divisible Goods [PDF]
We study the theory and practical implementation of auctioning many divisible goods. With multiple related goods, price discovery is important not only to reduce the winner’s curse, but more importantly, to simplify the bidder’s decision problem and to ...
Lawrence M. Ausubel, Peter Cramton
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 2018 We prove the existence conjecture for combinatorial designs, answering a question of Steiner from 1853. More generally, we show that the natural divisibility conditions are sufficient for clique decompositions of simplicial complexes that satisfy a ...
Keevash, Peter
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source