Results 181 to 190 of about 94,048 (263)

Linking factors affecting older adults' ability to live at home to increased workload perceptions among staff at general community support centers. [PDF]

J Rural Med
Nakai H, Ishii K.
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Essentials of Compassionate End-of-life Care in the Intensive Care Unit: Lessons from the Harish Rana Case. [PDF]

Indian J Crit Care Med
Mani RK.
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Burnout, associated factors and coping strategies among nursing professionals in Kerala, India: a cross-sectional study. [PDF]

BMJ Open
Ambujam JK, Francis PT, Olickal JJ, Sarma PS, Thankappan KR.   +4 more
europepmc   +1 more source

Group Duties: Their Existence and Their Implications for Individuals, by Stephanie Collins

Mind, 2020
openaire   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Determining the Causes of Mental Health Issues in Airline Pilots: The Role of Working Conditions and Workload in Predictive Models. [PDF]

Cureus
Schad E, Knueppel T, Pfoertner TK.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Survey of work-from-home experiences among medical physicists in Southern California during and after the COVID-19 pandemic. [PDF]

J Appl Clin Med Phys
Liu X, Zhang J, Hoffman D, Sehgal V, Shen ZL, Shi C, Qi XS, Cui J, Yu AS, Barker M, Ruan D, Goetsch S.   +11 more
europepmc   +1 more source