Results 81 to 90 of about 16,434,534 (365)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

RCT of post-conflict trauma interventions in the Central African Republic

open access: yesCambridge Prisms: Global Mental Health
This study evaluates mental health treatment in a post-conflict setting with scant mental health resources. The study reports on a randomized crossover control group design with one intervention and two control groups implemented in the Central African ...
William John Froming   +4 more
doaj   +1 more source

The Psychological Capital of Left-Behind University Students: A Description and Intervention Study From China

open access: yesFrontiers in Psychology, 2018
The migrant worker phenomenon in China has negatively impacted the psychological development of these workers' children, whom researchers have termed “left-behind children” (LC) or university students with left-behind experience (USWL).
Li Liang   +3 more
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

The efficacy of a clustered group-based acceptance and commitment therapy for patients with chronic pain — a randomized controlled semi-crossover trial

open access: yesCanadian Journal of Pain
Purpose The efficacy of Acceptance and Commitment Therapy (ACT) for chronic pain when provided as weekly sessions, is well documented. In scarcely populated areas, the traveling distance may be a barrier to weekly attendance. This study aimed to test the
Lena Danielsson   +3 more
doaj   +1 more source

Avaliação dos efeitos de uma modalidade de treinamento de habilidades sociais para crianças Evaluation of the effects of the social skills training method to children

open access: yesPsicologia: Reflexão e Crítica, 2008
Este artigo descreve os efeitos de uma intervenção em habilidades sociais sobre comportamentos pró-sociais, autoconceito e aceitação pelos pares, em três crianças: P.1, comportamento agressivo e dificuldade de aprendizagem, gênero feminino, 9 anos; P.2 ...
Elaine Sabino Gonçalves   +1 more
doaj   +1 more source

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