Results 191 to 200 of about 174,489,474 (248)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

open access: yesAdvanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li   +11 more
wiley   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

open access: yesAdvanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko   +8 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

Groups of Companies

1989
The basic unit of charge to corporation tax is an individual company. For certain purposes, however, the corporation tax legislation looks beyond the separate company to companies associated with it in a group of companies. Sometimes taking account of companies in the group has the effect of restricting or limiting some relief or benefit — e.g., in the
H. C. D. Rankin, D. M. Catterall
openaire   +1 more source

Bukhari Group of Companies

Indian Institute of Management Ahmedabad, 2014
Quality management among multiple business units of a large organization is often difficult if each unit is run independently in terms on their quality standards. In this case, participants will discuss how Bukhari Group of Companies should establish a common brand image through standardized quality.
Shamkant Damle, Debjit Roy
openaire   +2 more sources

VAT and Group Companies

Bulletin for International Taxation, 2011
This article summarizes the contents of Seminar D of the 64th Congress of the International Fiscal Association Congress held in Rome on 31 August 2010, which considered issues relating to VAT and GST with regard to group companies.
A. Parolini   +5 more
openaire   +1 more source

The governance of company groups

OECD Corporate Governance Working Papers, 2021
The majority of listed companies are part of a group linked through ownership and/or other mechanisms to exercise control. The popularity of group structures is based on a number of economic and legal advantages, including facilitating the supply of goods and services, economies of scale, reaching new markets or new activities, sharing the provisions ...
openaire   +3 more sources

Company Profile: QuantuMDx Group Limited

Pharmacogenomics, 2013
QuantuMDx Group Ltd (QMDx) is a group of companies based in the International Centre for Life, Newcastle upon Tyne, UK. The Group owns the founding patent and the exclusive worldwide license for, among others, the use of nanowires and nanotubes in DNA detection.
openaire   +3 more sources

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