Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Mathematical and Computer Modelling of Dynamical SystemsThis paper presents a K-dimensional system of an anti-periodic boundary value problem for nonlinear fractional differential equations with Riemann–Liouville–Caputo derivatives.
Man-Wen Tian +4 more
doaj +1 more source
Perbedaan Hasil Belajar Siswa Kelas X di SMA Negeri 1 Marawola melalui Penerapan Model Pembelajaran Kooperatif Tipe Buzz Group dan Konvensional pada Materi Sistem Periodik Unsur [PDF]
, 2015 Many efforts have been done in order to increase the quality of education. One of them is to improve the instructional process. The purpose of this research was to find out the difference of the grade X student's learning outcomes at SMA Negeri 1 ...
Ratman, R. (Ratman) +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cosmological-Billiards Groups and self-adjoint BKL Transfer Operators
, 2015 Cosmological billiards arise as a map of the solution of the Einstein equations, when the most general symmetry for the metric tensor is hypothesized, and points are considered as spatially decoupled in the asymptotic limit towards the cosmological ...
Lecian, Orchidea Maria
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Mechanical Properties of Two-Dimensional Metal Nitrides: Numerical Simulation Study
NanomaterialsIt is expected that two-dimensional (2D) metal nitrides (MNs) consisting of the 13th group elements of the periodic table and nitrogen, namely aluminium nitride (AlN), gallium nitride (GaN), indium nitride (InN) and thallium nitride (TlN), have enhanced ...
Nataliya A. Sakharova +2 more
doaj +1 more source
Penerapan Model Pembelajaran Accelerated Learning untuk Meningkatkan Prestasi Belajar Siswa pada Pokok Bahasan Struktur Atom dan Sistem Periodik Unsur di Kelas X Sman 14 Pekanbaru [PDF]
, 2016 The application of Accelerated Learning model aims to improve student achievement on subject of Atomic Structure and Periodic System Elements in class X SMAN 14 Pekanbaru.
Cahya, A. P. (Anggra) +2 more
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source