Results 131 to 140 of about 16,122,951 (300)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Early dye laser treatment of hypertrophic sternotomy scars with prominent vascular component

JPRAS Open
Purpose: A considerable percentage of patients develop hypertrophic scarring due to the healing process after heart surgery. The purpose of this study was to determine whether PDL applied on the day of suture removal, is even more successful in ...
Giovanni Cannarozzo, Laura Pieri, Lara Ronconi, Irene Fusco, Tiziano Zingoni   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Using a report card to increase HIV screening in a large primary care group practice. [PDF]

BMJ Open Qual, 2021
Luu MN, Wada PY, Levine-Hall T, Hurley L, Ramalingam N, Tran HN, Slome SB.   +6 more
europepmc   +1 more source

Development and optimisation of a reception testing protocol designed to eliminate HCV in the UK prison population

JHEP Reports
Background & Aims: Micro-elimination of hepatitis C virus (HCV) in high-risk populations is a feasible approach towards achieving the World Health Organization’s targets for viral hepatitis elimination by 2030.
Emily Mongale, Samantha Allen, Iain Brew, Arran Ludlow-Rhodes, Nichola Royal, Julia Waldron, Hannah Alexander, Lee Christensen, Kate Dorrington, Andrew Milner, Louise Missen, Andy Jones, Philip J.F. Troke   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Frequency of infection with Mycoplasma suis in gestating sows using qPCR on ten commercial French herds, and impact of the infection on clinical, haematological and biochemical parameters

Porcine Health Management, 2020
Mathieu Brissonnier, Valérie Normand, Arnaud Lebret, Pierre-Yves Moalic, Anne-Sophie Guyomard, Véronique Bachy, Pauline Berton, Vincent Auvigne, Franck Bouchet, Gwenaël Boulbria   +9 more
doaj   +1 more source

Scaling up evidence-based interventions to reduce maternal and child undernutrition in 125 countries: a cost-benefit analysis

International Journal for Equity in Health
Background The world is not on track to reach the Sustainable Development Goal nutrition targets. We aimed to estimate the cost, impact and benefit-cost ratio from scaling up 15 evidence-based nutrition interventions among 125 countries and seven world ...
Nick Scott, Tharindu Wickramaarachchi, Natalia Rovelo-Velázquez, Mireya Vilar-Compte   +3 more
doaj   +1 more source