Results 141 to 150 of about 17,848,914 (309)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

How Much Is Enough? An Empirical Test of the Resource Dispersion Hypothesis

Ecology and Evolution
Understanding how animals adjust their spatial and social organization to resource variability is central to ecological theory. We tested predictions of the Resource Dispersion Hypothesis (RDH) by examining how resource availability and distribution ...
Sourabh Biswas, Kalyan Ghosh, Sumedha Touhid, Srijaya Nandi, Arpan Bhattacharyya, Arunima Bhattacharyya, Milisha Das, Raktim Paul, Anindita Bhadra   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Estimating spatiotemporal reproductive dynamics of fish populations with passive acoustic monitoring: A state‐space model approach

Methods in Ecology and Evolution
Passive acoustic monitoring (PAM) has been used to estimate the presence and spatial distribution of target organisms using biological sounds received by microphones.
Keisuke Ota, Tomonari Akamatsu, Yutaka Osada, Michio Kondoh   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Group size effect for group based networks.

, 2014
The effect of group size for networks at a density of 5% (top row), 20% (second row), 45% (third row) and the weighted network (bottom row). A bootstrapping procedure was used (100 realizations) to randomly group the subjects with increasing group size ...
Katarzyna Adamczuk (674076), Rik Vandenberghe (674079), Yu Wang (12152), Natalie Nelissen (674075), Stefan Sunaert (407984), An-Sofie De Weer (674077), Mathieu Vandenbulcke (674078), Patrick Dupont (407983)   +7 more
core   +1 more source

Gazing Strategies among Sentinels of a Cooperative Breeder Are Repeatable but Unrelated to Survival

Biology
Vigilance is a common behavioural adaptation to increase the chances of detecting predators before it is too late to escape. Behavioural traits are often repeatable among individuals over the long term, suggesting differences in personality.
Guy Beauchamp, Sahas Barve
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Group size and composition of Guiana dolphins (Sotalia guianensis) (Van Bénèden, 1864) in the Paranaguá Estuarine Complex, Brazil

Brazilian Journal of Biology
The aim of the present study was to describe the characteristics of Guiana dolphins (S. guianensis) group size and composition in the Paranaguá Estuarine Complex (25° 15' -25° 36' S and 48° 02'-48° 45' W), Paraná State, as well as to verify the existence
MCO. Santos, JEF. Oshima, ES. Pacífico, E. Silva   +3 more
doaj   +1 more source