Results 251 to 260 of about 18,357,901 (314)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Interactions with Locust Bean Gum Regulate the Gelling Capacity of Myofibrillar Protein Emulsion: Effects of Locust Bean Gum Concentration. [PDF]

Foods
Ru A, Bai X, Wang K, Yin F, Wang X, Zhu C, Zhao G, Tong L, Han G.   +8 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Beyond mere novelty: Categorization drives differentiation. [PDF]

Br J Soc Psychol
Rothermund P, Deutsch R.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Anti-idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes. [PDF]

Protein Sci
Itou H, Sano K, Ainai A, Otsuki K, Inoue T, Hemmi T, Hasegawa H, Suzuki T.   +7 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Analysis of Inbreeding, Population Structure, and Genetic Diversity in the Kumamoto Sub-Breed of Japanese Brown Cattle. [PDF]

Animals (Basel)
Wang T, Inoue K, Ichinoseki K, Takeda M, Fukuzawa Y, Ozaki T, Peng W, Wang G, Ishida T.   +8 more
europepmc   +1 more source

Regulatory Effect of Polyacrylate Emulsion on the NaCl Attack Behavior of Cement-Based Grouting Materials. [PDF]

Polymers (Basel)
Wang Y, Han S, Wang F, Hu L, Liao J, Zhu S, Li Y, Wu J.   +7 more
europepmc   +1 more source

Identification of a key water molecule involved in the macrophage migration inhibitory factor-catalyzed tautomerization of para-hydroxyphenylpyruvate using neutron crystallography. [PDF]

Protein Sci
Schröder GC, Crichlow GV, Jablonowski E, Pantouris G, Nix J, Chayen N, Meilleur F, Lolis EJ.   +7 more
europepmc   +1 more source