Results 171 to 180 of about 10,930,999 (239)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Acceptability and feasibility of the Ushirikiano treatment model for Kenyan adolescents: a pilot randomized controlled trial. [PDF]

Front Child Adolesc Psychiatry
Ali NA, Mwavua SM, Yator O, Kathono J, Huizink AC, Kumar M.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Factors associated with successful psychiatric intensive home treatment - a quasi-experimental study. [PDF]

Front Psychiatry
Weinmann S, Nikolaidis K, Längle G, von Peter S, Brieger P, Timm JE, Fischer L, Dreher M, Raschmann S, Holzke M, Schwarz J, Hardt O, Hirschmeier C, Herwig U, Klingberg S, Kilian R, Baumgardt J, Hamann J, Bechdolf A.   +18 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Proposal of a new tool for paediatric primary spontaneous pneumothorax: the Spontaneous Pneumothorax in Adolescents and Children Evaluation (SPACE) score. [PDF]

Front Pediatr
Frediani S, Aloi IP, Zarfati A, Paradiso FV, Pardi V, Silvaroli S, Accinni A, Beati F, Bertocchini A, Madafferi S, Rollo G, Inserra A, Nanni L.   +12 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

<i>HLA-DRB1*14</i> is associated with lower odds of symptomatic SARS-CoV-2 infection in Mexican individuals. [PDF]

Front Immunol
Hernández EG, Daza-Mendoza DA, González-Rivas E, Serrano-Vázquez A, Pérez-Juárez H, Uribe-García A, Rostro-Alonso GO, Morán-Silva P, Rojas-Velázquez L, Ximénez García C.   +9 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Remotely Supervised, Home-Based Transcranial Direct Current Stimulation for Major Depressive Disorder: Systematic Review and Meta-Analysis. [PDF]

JMIR Ment Health
Haimi M, Almeida-Antunes N, Rodrigues Ferreira SP, Barbosa Rocha N.   +3 more
europepmc   +1 more source