Results 61 to 70 of about 2,823,093 (309)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Perbandingan Efektifitas Antara Metode Pembelajaran Psikomotor Di Laboratorium Dengan Supervisi Dan Mandiri Terhadap Kemampuan Melakukan Keterampilan Psikomotor Pada Mata Ajar Keperawatan Dasar [PDF]

, 2005
:It has been widely acknowledged that an effective and innovative teaching method for psychomotor skills at the laboratory was needed. This study was aimed at comparing the effectiveness between teaching method for psychomotor skills with supervision and
Afifah, E. (Efy), Asih, I. D. (Imalia), Sumarwati, M. (Made)   +2 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Research on Intelligent Control Platform in Urban Rail Transit FAO Scenario

Chengshi guidao jiaotong yanjiu
[Objective] The existing operational mechanisms primarily rely on operational management systems that drive personnel to perform operational tasks. Operational staff communicate information through phones or intercom devices and issue operational control
Chunming ZHANG
doaj   +1 more source

A peer-driven community-based supervisory model: development from an evaluation of an ethics workshop for doctoral students undertaking research with children [PDF]

, 2014
Differing doctoral supervision models currently exist. Three key conceptual supervisory models relevant to doctoral students from within the healthcare professions were identified from a literature review: the ‘functional pre-modern’ model, the ‘team ...
Hunt, Jane, Swallow, Veronica
core  

A randomized controlled trial of training in Motivational Interviewing for child protection. [PDF]

, 2018
There has been interest in developing more evidence-based approaches to child and family social work in the UK in recent years. This study examines the impact of a skills development package of training and supervision in Motivational Interviewing (MI ...
Antonopoulou, Paraskevi, Antonopoulou, Vivi, Forrester, Donald, Hutchison, Dougal, Killian, Mike, McCann, Michelle, Thomas, Roma-Joy, Thurnham, Angela, Waits, Charlotte, Westlake, David, Whittaker, Charlotte   +10 more
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Coupling Characteristics of Operational Safety Risks in Urban Rail Transit

Chengshi guidao jiaotong yanjiu
Objective Urban rail transit system is a complex integrated system involving people, machine, environment, and management, with its operational risks existing not independently or statically.
SHI Ting
doaj   +1 more source